Fig. 1

a Photomicrograph of liver section from control rat showing normal hepatic architecture with cords of hepatocytes radiating from the central vein and separated by blood sinusoids (H&E ×400). b Photomicrograph of liver section from treated rat of low dose revealing vacuolar changes (arrow with two heads), inflammatory cells (black arrow), and distended sinusoidal space (white arrow) (H&E ×400). c Photomicrograph of liver section from treated rat of high dose showing increased inflammatory infiltration (black arrow) and distended sinusoidal space (arrow with two heads) (H&E ×400). d Photomicrograph of liver section from treated rat of high dose showing pyknotic nuclei (black arrow) and swelled vacuolized hepatocyte (black arrow with two heads). e Photomicrograph of liver section from treated rat of high dose showing an increase in Kupffer cells (black arrow with two heads) (H&E ×400). f Photomicrograph of liver section from treated rat of high dose showing eosinophilic material (black arrow), infiltration of inflammatory cells (black arrow with two heads), and distorted hepatic architecture (H&E ×400). g Photomicrograph of liver section from treated rat of high dose showing distorted hepatic architecture, pyknotic nuclei (white arrow), hyaline material (black arrow), and inflammatory cells (black arrow with heads) (H&E ×400)