TY - JOUR AU - Ahmed, Rania A. PY - 2018 DA - 2018/01/30 TI - Hepatoprotective and antiapoptotic role of aged black garlic against hepatotoxicity induced by cyclophosphamide JO - The Journal of Basic and Applied Zoology SP - 8 VL - 79 IS - 1 AB - Cyclophosphamide (CP) is an anticancer drug utilized for treatment of many types of cancer. CP causes many side effects such as hepatotoxicity and mutagenicity. Garlic has long been used as a spice and food additive and is considered as one of the important medicinal plants. Garlic had medicinal importance as it has hepatoprotective, antimicrobial, antioxidant, anti-inflammatory, antithrombotic, antihypertensive, and antihyperlipidemic properties. The purpose of the presented study is to investigate the protective role of aged black garlic against cyclophosphamide-induced hepatotoxicity and apoptosis. The present work was carried out by routine histological H&E stain, histochemical Feulgen stain for DNA, immunohistochemical stain Bcl-2 as apoptotic marker, comet assay, serum biochemical analysis for liver function markers (ALT, AST, albumin, and bilirubin), and hepatic oxidative stress markers (MDA, CAT, SOD, and GPx). SN - 2090-990X UR - https://doi.org/10.1186/s41936-018-0017-7 DO - 10.1186/s41936-018-0017-7 ID - Ahmed2018 ER -