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Table 1 The experimental design

From: A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

Groups

Concentration and volume of Fl/EGCG/vehicle administrated

Treatment period

Sacrifice

Group I (Control)

0.5 ml of slain solution administrated as vehicle/day

4 weeks

29th day

Group II (EGCG alone)

EGCG 40 mg/kg bw (1.6 ml) per day by intragastric administration

4 weeks

29th day

Group III (Fl as NaF alone)

Fl as NaF 25 mg/kg bw (2.5 ml) per day by intragastric administration

4 weeks

29th day

Group IV (Pre-treatment with EGCG followed by NaF)

EGCG 40 mg/kg bw (1.6 ml) administrated 30 min before administration of NaF (2.5 ml) per day by intragastric administration

4 weeks

29th day