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Table 1 The experimental design

From: A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

Groups Concentration and volume of Fl/EGCG/vehicle administrated Treatment period Sacrifice
Group I (Control) 0.5 ml of slain solution administrated as vehicle/day 4 weeks 29th day
Group II (EGCG alone) EGCG 40 mg/kg bw (1.6 ml) per day by intragastric administration 4 weeks 29th day
Group III (Fl as NaF alone) Fl as NaF 25 mg/kg bw (2.5 ml) per day by intragastric administration 4 weeks 29th day
Group IV (Pre-treatment with EGCG followed by NaF) EGCG 40 mg/kg bw (1.6 ml) administrated 30 min before administration of NaF (2.5 ml) per day by intragastric administration 4 weeks 29th day
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