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Fig. 4 | The Journal of Basic and Applied Zoology

Fig. 4

From: Toxicological studies on commercial hair dye brand commonly used in Saudi Arabia: histological study of the liver, kidney, heart, and testis

Fig. 4

Sections from the rat kidney show renal tubules of the following: G1: Co (control) group, proximal tubules (dotted circles) showing intact pyramidal cells surrounded by narrow lumen (stars), the cytoplasm highly acidophilic and rounded, vesicular (active) nuclei (arrows) are H-E, × 400. G2: LD dye (low dose) showing slight changes in proximal tubules in the form of increase cytoplasmic acidophilia and density of nuclei staining (signs of early apoptosis). Distal tubules showed dilated lumina with decrease height of lining epithelium. Some tubular cells showed unstained cytoplasm (H-E, × 400). G2-a: LD dye (low dose) showing slight changes in proximal tubules in the form of increase cytoplasmic acidophilia and density of nuclei staining (signs of early apoptosis). Distal tubules showed dilated lumina with decrease height of lining epithelium. G2-b: LD dye showed loss of tubular outlines. The lumina were obliterated. The cytoplasm of cells is deeply stained, and the nuclei become smaller and deeply stained (signs of apoptosis). (H-E, × 400). G3: HD dye (high dose) showing disorganization of tubular shape, dilation (arrows), and signs of cell degeneration (unstained cytoplasm (dotted circles) with decrease nuclear size (dark stained) (white arrows) (H-E, × 400)

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