Counter effect of bee venom and its extracted bradykinin-potentiating factor on acrylamide and chips administration-induced complications in the liver and kidney of male mice

The Journal of Basic and Applied Zoology

Table 4 Effect of BV and BPF treatment on acrylamide and chips administration on the plasma creatinine (mg/dl), urea (mg/dl), and uric acid (mg/dl) of mice for 60 days

		Cont.	Acr.	Chip.	BV	BPF	Acr + BV	Acr + BPF	Chip + BV	Chip + BPF
Creatinine Mean ± SE		0.842 ± 0.04	4.036 ± 0.25^a**	2.69 ± 0.344^{a, b}**	0.79 ± 0.08^{b, c}**	0.86 ± 0.041^{b, c}**	1.21 ± 0.12^{b, c}**	1.062 ± 0.102^{b, c}**	1.226 ± 0.17^{b, c}**	1.05 ± 0.141^{b, c}**
% of change	(1)		+ 379.33	+ 219.47	− 6.17	+ 2.13	+ 33.01	+ 26.12	+ 45.60	+ 24.70
	(2)			− 33.35	− 80.46	− 78.69	− 70.62	− 73.68	−69.77	− 73.98
	(3)				− 70.63	− 68.03	− 55.02	− 60.59	− 54.42	− 60.96
Urea Mean ± SE		29.46 ± 2.61	57.36 ± 6.85^a**	46.1 ± 3.71^{a, b}**	29.74 ± 1.42^{b, c}**	29.42 ± 2.35^{b, c}**	26.92 ± 1.83^{b, c}**	28.66 ± 2.98^{b, c}**	35.34 ± 2.22^b*^{, c}	33.68 ± 1.63^b*^{, c}
% of change	(1)		+ 94.70	+ 56.48	+ 0.95	− 0.13	− 8.62	− 2.71	+ 30.14	+ 14.32
	(2)			−19.63	− 48.15	− 48.71	− 53.06	− 50.03	− 38.39	− 41.28
	(3)				− 35.49	− 33.97	− 41.60	− 37.83	− 23.34	− 26.94
Uric acid Mean ± SE		5 ± 0.71	19.8 ± 2.22^a**	17.8 ± 1.93^a**	4.8 ± 0.8^{b, c}**	5.2 ± 0.58^{b, c}**	4.8 ± 0.73^{b, c}**	5.8 ± 0.73^{b, c}**	8.2 ± 1.067^a, ^{b, c}*	8.6 ± 1.029^{a, c}^{, b}*
% Of Chang	(1)		+ 296	+ 256	− 4	+ 4	− 4	+ 16	+ 64	+ 72
	(2)			− 10.10	− 75.75	− 73.73	− 75.75	− 70.70	− 58.58	− 56.56
	(3)				− 73.03	− 70.78	− 73.03	−67.41	− 53.93	− 51.68

Significance difference between control and treated groups. n = 5. % of change: (1) from control, (2) from acrylamide, (3) from chips
*P < 0.05 significant, **P < 0.001 highly significant
^aSignificance difference to control
^bSignificance difference to acrylamide
^cSignificance difference to chips