Fig. 2
From: The ameliorative impacts of curcumin on copper oxychloride-induced hepatotoxicity in rats
a Section of liver from a rat treated with 500 mg/kg body weight COC for 90 days showing congestion of central vein (CV) and cytoplasmic vacuolization of the hepatocytes (arrows), × 400. b Liver section obtained from a rat treated with 500 mg/kg COC; the restoration of the normal arrangement of the hepatocytes and giant multinucleate cells (GMC). c Section of liver from a rat treated with 1000 mg/kg body weight COC for 90 days showing hydrobic degeneration (H) appeared as cytoplasmic vacuolization of the hepatocytes and increase of pyknotic cells. d Section of liver from a rat treated with 1000 mg/kg body weight COC and curcumin for 3 months showing hydrobic degeneration (H) appeared as cytoplasmic vacuolization of the hepatocytes and absence of pyknotic cells. e Liver section of a rat examined after 90 days of treatment with 2000 mg/kg body weight COC shows a large mass of inflammatory infiltration in the portal area (P). f Liver section obtained from a rat treated with 2000 mg/kg body weight COC followed with curcumin extract for 90 days showing improvement of hepatic tissue and decreasing the mass of inflammatory infiltration in the portal area (P), H&E, × 400