Fig. 4

F2 group liver showing a focal necrotic area (↑), foci of cellular infiltration around the portal area (I), leucocytic aggregation between liver cells (↑↑), and vacuolation and degeneration of many hepatocytes (H&E). b Many of mast cells between portal areas (↑) (toluidine blue stain). c Large dilatation of blood sinusoids filled with deformed RBCs (↑), highly vacuolated cytoplasm of many hepatocytes (↑↑), and pyknotic nuclei (arrowhead). Note: deposition of RBCs debris in the wall of blood sinusoids (toluidine blue stain). d Ultrastructure of hepatocytes showing deformed RBCs with thickened their plasma membrane (↑) and the nuclei of endothelial cell appeared irregular in shape with condensed chromatin (↑↑). e Ultrastructure of hepatocytes showing destructed mitochondria (M) and fragmented rough endoplasmic reticulum (RER). Note: degenerated nuclei