Fig. 8

F4 group liver showing a large necrotic area with leucocytic aggregation and hemorrhage (H&E). b F4 group liver showing A congested blood sinusoids and damage of their walls led to the fusion of their lumens (toluidine blue stain). B Most cells depleted from the cytoplasm (↑) and degeneration of most of the nuclei (↑↑) (toluidine blue stain). c Ultrastructure of hepatocytes showing three degenerated nuclei (N); one of them their nuclear membrane was damaged (↑). Large empty spaces due to the destruction of most cell organoids (↑↑). d Ultrastructure of hepatocytes showing three nuclei, one of them their nuclear membrane was damaged (↑↑), the other one showed separation between their inner and outer membrane (↑) while the last one appears degenerated (arrowhead)