Genotoxicity and oxidative stress induced by the orally administered nanosized nickel and cobalt oxides in male albino rats

The Journal of Basic and Applied Zoology

Table 1 The experimental design of the study

Group	Control	Experimental groups
	Control	NiO-NPs alone		Co₃O₄-NPs alone		Mixed groups
	I	II	III	IV	V	VI	VII
Sample size	15 rats	15 rats	15 rats	15 rats	15 rats	15 rats	15 rats
0.5%CMC	+++	+++	+++	+++	+++	+++	+++
NiO-NPs	–	0.5 g/kg	1.0 g/kg	–	–	0.25 g/kg	0.5 g/kg
Co₃O₄-NPs	–	–	–	0.5 g/kg	1.0 g/kg	0.25 g/kg	0.5 g/kg
Route	Oral	Oral	Oral	Oral	Oral	Oral	Oral
Frequency	Single	Single	Single	Single	Single	Single	Single
Sampling time	After 1, 7, and 14 days of administration