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Table 5 Fitting equations and correlation coefficients (r) of SOD activity (y) with the levels of Zn (x1) as well as the expression levels of SOD gene (x2) in the brain, liver, and kidneys of rats administered 0.5g and 1.0g of NiO-NPs (II and III), 0.5g and 1.0g of Co3O4-NPs (IV and V), as well as mixtures of NiO-NPs + Co3O4-NPs (0.25g + 0.25g, VI) and (0.5g + 0.5g, VII) per kilogram body weight, respectively

From: Genotoxicity and oxidative stress induced by the orally administered nanosized nickel and cobalt oxides in male albino rats

.Variables Experimental group
y x   II III IV V VI VII
SOD activity (U/g tissue) Zn levels (μg/g tissue) Brain y = 0.13x1 − 0.01
r = + 0.87***
y = 0.10x1 + 0.28
r = + 0.94***
y = 0.15x1 −  0.33
r = + 0.93***
y = 0.13x1 + 0.08
r = + 0.93***
y = 0.09x1 + 0.69
r = + 0.88***
y = 0.06 x1 + 1.28
r = + 0.88***
Liver y = 0.02x1 − 0.09
r = + 0.68**
y = 0.02x1 − 0.10
r = + 0.85***
y = 0.01x1 + 0.12
r = + 0.65**
y = 0.02x1 − 0.20
r = + 0.69**
y = 0.01x1 + 0.08
r = + 0.50*
y = 0.02x1 − 0.22
r = + 0.90***
Kidney y = 0.06x1 + 0.69
r = + 0.81***
y = 0.13x1 − 0.40
r = + 0.75***
y = 0.10x1 + 0.12
r = + 0.89*
y = 0.04x1 + 1.17
r = + 0.61*
y = 0.05x1 + 1.08
r = + 0.96***
y = 0.06x + 0.93
r = + 0.78***
SOD gene (expression level) Brain y = 5.15x2 −  1.26
r = + 0.94***
y = 4.02x2 − 0.80
r = + 0.89***
y = 4.56x2 − 0.98
r = + 0.94***
y = 2.64x2 + 0.02
r = + 0.99***
y = 2.27x2 + 0.28
r = + 0.91***
y = 1.33x2 + 1.13
r = + 0.79***
Liver y = 0.67x − 0.07
r = + 0.89***
y = 0.84x2 − 0.19
r = + 0.96***
y = 0.49x2 + 0.06
r = + 0.68**
y = 0.44x2 + 0.11
r = + 0.62*
y = 0.39x2 + 0.15
r = + 0.82***
y = 0.42x2 + 0.15
r = + 0.86***
Kidney y = 1.52x2 + 1.07
r = + 0.84***
y = 1.73x2 + 0.99
r = + 0.84***
y = 2.07x2 + 0.84
r = + 0.94***
y = 1.18x2 + 1.20
r = + 0.76***
y = 0.79x2 + 1.46
r = + 0.95***
y = 1.00x2 + 1.44
r = + 0.92***
  1. *, **, ***: significant correlations between the studied variables at P<0.05, P<0.01 and P<0.001, respectively