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Table 2 Mean parentages ± SEM of chromosomal aberration in bone marrow cells of MMC-treated mice supplemented with different doses (50 and 100 mg/kg body wt) of Nitraria retusa leaf extracts at different time intervals (3 days, 1 week, and 1 month)

From: Antioxidant capacity of Nitraria retusa leaf extracts against mitomycin C-induced genetic toxicity in male mice

Groups Structural aberrations Total structural aberrations Numerical variation Total
Gap Break Chromatid break Deletions Fragments End-to-end N − 1 N + 1  
Control 0.80 ± 0.04d 0.40 ± 0.02e 0.60 ± 0.03c 0.20 ± 0.02c 0.20 ± 0.02e 0.20 ± 0.02d 2.40 ± 0.04e 0.40 ± 0.11d 0.20 ± 0.14c 0.60 ± 0.02d
MMC 6.70 ± 0.12a 7.40 ± 0.14a 3.30 ± 0.12a 5.20 ± 0.14a 7.80 ± 0.13a 5.20 ± 0.14a 35.60 ± 0.16a 4.40 ± 0.17a 3.20 ± 0.13a 7.60 ± 0.11a
MMC + NR50 3 days 5.40 ± 0.08a 4.80 ± 0.13b 2.70 ± 0.06ab 4.80 ± 0.02a 6.20 ± 0.04ab 6.40 ± 0.04a 30.30 ± 0.22ab 3.60 ± 0.02ab 3.10 ± 0.04ab 6.70 ± 0.03a
MMC + NR100 3 days 5.10 ± 0.07a 3.40 ± 0.14bc 2.40 ± 0.12ab 3.60 ± 0.05ab 5.20 ± 0.11b 5.40 ± 0.08a 25.10 ± 0.32b 2.80 ± 0.06b 3.00 ± 0.04ab 5.80 ± 0.12ab
MMC + NR50 1 week 4.60 ± 0.04ab 3.20 ± 0.11bc 2.20 ± 0.12b 2.60 ± 0.08b 5.10 ± 0.09b 4.60 ± 0.04ab 22.30 ± 0.50bc 2.40 ± 0.06b 2.50 ± 0.12b 4.90 ± 0.14ab
MMC + NR100 1 week 3.80 ± 0.12b 2.60 ± 0.15c 2.40 ± 0.11ab 2.40 ± 0.08b 4.60 ± 0.06bc 3.20 ± 0.11b 19.00 ± 0.42c 2.10 ± 0.08b 1.80 ± 0.11bc 3.90 ± 0.12b
MMC + NR50 1 month 2.60 ± 0.12c 1.80 ± 0.06cd 1.70 ± 0.04b 1.60 ± 0.08bc 3.10 ± 0.12c 2.60 ± 0.04b 13.40 ± 0.14cd 1.60 ± 0.08bc 1.40 ± 0.05bc 3.00 ± 0.12b
MMC + NR100 1 month 2.10 ± 0.08c 1.20 ± 0.04d 0.80 ± 0.09c 0.80 ± 0.11c 1.60 ± 0.08d 2.10 ± 0.08c 8.60 ± 0.12d 1.20 ± 0.08c 0.60 ± 0.05c 1.80 ± 0.12c
  1. MMC mitomycin C, NR Nitraria retusa leaf extracts
  2. a,b,c,dDifferent small superscript letters are differing significantly