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Table 2 Mean parentages ± SEM of chromosomal aberration in bone marrow cells of MMC-treated mice supplemented with different doses (50 and 100 mg/kg body wt) of Nitraria retusa leaf extracts at different time intervals (3 days, 1 week, and 1 month)

From: Antioxidant capacity of Nitraria retusa leaf extracts against mitomycin C-induced genetic toxicity in male mice

Groups

Structural aberrations

Total structural aberrations

Numerical variation

Total

Gap

Break

Chromatid break

Deletions

Fragments

End-to-end

N − 1

N + 1

 

Control

0.80 ± 0.04d

0.40 ± 0.02e

0.60 ± 0.03c

0.20 ± 0.02c

0.20 ± 0.02e

0.20 ± 0.02d

2.40 ± 0.04e

0.40 ± 0.11d

0.20 ± 0.14c

0.60 ± 0.02d

MMC

6.70 ± 0.12a

7.40 ± 0.14a

3.30 ± 0.12a

5.20 ± 0.14a

7.80 ± 0.13a

5.20 ± 0.14a

35.60 ± 0.16a

4.40 ± 0.17a

3.20 ± 0.13a

7.60 ± 0.11a

MMC + NR50 3 days

5.40 ± 0.08a

4.80 ± 0.13b

2.70 ± 0.06ab

4.80 ± 0.02a

6.20 ± 0.04ab

6.40 ± 0.04a

30.30 ± 0.22ab

3.60 ± 0.02ab

3.10 ± 0.04ab

6.70 ± 0.03a

MMC + NR100 3 days

5.10 ± 0.07a

3.40 ± 0.14bc

2.40 ± 0.12ab

3.60 ± 0.05ab

5.20 ± 0.11b

5.40 ± 0.08a

25.10 ± 0.32b

2.80 ± 0.06b

3.00 ± 0.04ab

5.80 ± 0.12ab

MMC + NR50 1 week

4.60 ± 0.04ab

3.20 ± 0.11bc

2.20 ± 0.12b

2.60 ± 0.08b

5.10 ± 0.09b

4.60 ± 0.04ab

22.30 ± 0.50bc

2.40 ± 0.06b

2.50 ± 0.12b

4.90 ± 0.14ab

MMC + NR100 1 week

3.80 ± 0.12b

2.60 ± 0.15c

2.40 ± 0.11ab

2.40 ± 0.08b

4.60 ± 0.06bc

3.20 ± 0.11b

19.00 ± 0.42c

2.10 ± 0.08b

1.80 ± 0.11bc

3.90 ± 0.12b

MMC + NR50 1 month

2.60 ± 0.12c

1.80 ± 0.06cd

1.70 ± 0.04b

1.60 ± 0.08bc

3.10 ± 0.12c

2.60 ± 0.04b

13.40 ± 0.14cd

1.60 ± 0.08bc

1.40 ± 0.05bc

3.00 ± 0.12b

MMC + NR100 1 month

2.10 ± 0.08c

1.20 ± 0.04d

0.80 ± 0.09c

0.80 ± 0.11c

1.60 ± 0.08d

2.10 ± 0.08c

8.60 ± 0.12d

1.20 ± 0.08c

0.60 ± 0.05c

1.80 ± 0.12c

  1. MMC mitomycin C, NR Nitraria retusa leaf extracts
  2. a,b,c,dDifferent small superscript letters are differing significantly