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Table 4 Rate of DNA damage in liver tissues of MMC-treated mice supplemented with different doses (50 and 100 mg/kg body wt) of Nitraria retusa leaf extracts at different time intervals (3 days, 1 week, and 1 month) using comet assay

From: Antioxidant capacity of Nitraria retusa leaf extracts against mitomycin C-induced genetic toxicity in male mice

Treatment No. of cells Class¥ of comet DNA damaged cells (mean ± SEM)
Analyzed* Total comets 0 1 2 3
Control 500 31 469 24 7 0 6.2 ± 0.26e
MMC 500 137 363 29 47 61 27.4 ± 0.22a
MMC + NR50 3d 500 113 387 31 38 44 22.6 ± 0.35b
MMC + NR100 3 days 500 104 396 28 35 41 20.8 ± 0.42bc
MMC + NR50 1w 500 91 409 23 32 36 18.2 ± 0.28c
MMC + NR100 1 week 500 74 426 24 29 21 14.8 ± 0.45cd
MMC + NR50 1 month 500 51 449 22 17 12 10.2 ± 0.33d
MMC + NR100 1 month 500 42 458 19 15 8 8.4 ± 0.25de
  1. ¥Class 0 = no tail; 1 = tail length < diameter of nucleus; 2 = tail length between 1× and 2× the diameter of nucleus; and 3 = tail length > 2× the diameter of nucleus. *No of cells analyzed were 100 per an animal
  2. a, b, c, d, e Different small superscript letters are differing significantly.