Fig. 2

A photomicrograph of liver sections. a Control group showing normal hepatic architectures with polygonal hepatocyte (H), normal central vein (CV), and sinusoid (S). b1 Mice treated with cadmium only showing scattered areas of fatty change (f) in most hepatocyte and diffused extensive congested central vein (CV) with dilated congested portal vein (pv), and proliferated bile duct (b). b2 Mice treated with cadmium only showing severe dilated congested central vein (cv), few enucleated hepatocyte (u), scattered dense aggregation of inflammatory cells (IF), and hemorrhage (he). Hepatocyte with pyknotic nucleus and severe vacuolated cytoplasm (H) together with edema (o) were also seen. b3 Mice treated with cadmium only showing scattered necrotic areas (N), severe dilated congested central vein (cv), and hemorrhage (h). Hepatocyte with pyknotic nucleus and severe vacuolated cytoplasm (H) together with edema (o) were also seen. c Mice treated with nano-chocolate fortified with zinc only showing hepatocyte with vesicular nucleolus (H) and normal appearance of both central vein (CV) and sinusoid (s). d Mice treated with cadmium and nano-chocolate fortified with zinc showing normal histological structure : normal shape of hepatocyte (H) radiated in columns from central vein (CV) and separated by sinusoid (s) (H & E X 200)