Biochemical and Histopathological studies on female and male Wistar rats fed on genetically modified soybean meals (Roundup Ready)

Eissa, Marwa Ibrahim; El-Sherbiny, Mohammed Ahmed; Ibrahim, Ayman Maher; Abdelsadik, Ahmed; Mohamed, Mona Mostafa; El-Halawany, Medhat Salah

doi:10.1186/s41936-019-0114-2

The Journal of Basic and Applied Zoology

Table 6 The effect of gender, percentage of GM soybean in the experimental diets (0%, 50%, and 100% GM soya), and their interaction on the level of examined biochemical parameters in serum of albino rats. Results are represented as mean ± standard error of mean

From: Biochemical and Histopathological studies on female and male Wistar rats fed on genetically modified soybean meals (Roundup Ready)

Parameter	Experimental group				Effect of
Parameter	Gender	Control	T1	T2	Gender	Diet	Interaction
TG (mg/dl)	Female	46.86 ± 1.80^A	63.08 ± 3.58^B	61.32 ± 5.43^B	F1, 24 = 0.009, P > 0.05	F2, 24 = 4.70, P < 0.05	F2, 24 = 2.37, P > 0.05
TG (mg/dl)	Male	53.52 ± 3.98^A	52.66 ± 2.59^A	64.10 ± 5.79^A	F1, 24 = 0.009, P > 0.05	F2, 24 = 4.70, P < 0.05	F2, 24 = 2.37, P > 0.05
Chol (mg/dl)	Female	65.06 ± 3.26^A	67.26 ± 6.44^A	51.88 ± 4.70^A	F1, 24 = 3.98, P > 0.05	F2, 24 = 1.06, P > 0.05	F2, 24 = 2.39, P > 0.05
Chol (mg/dl)	Male	65.02 ± 0.73^A	71.14 ± 4.84^A	72.20 ± 6.96^A*	F1, 24 = 3.98, P > 0.05	F2, 24 = 1.06, P > 0.05	F2, 24 = 2.39, P > 0.05
HDL	Female	43.99 ± 1.76^A	44.23 ± 3.60^A	35.77 ± 3.79^A	F1, 24 = 0.23, P > 0.05	F2, 24 = 0.73, P > 0.05	F2, 24 = 3.49, P > 0.05
HDL	Male	37.12 ± 0.85^A*	40.86 ± 1.79^A	42.79 ± 3.25^A	F1, 24 = 0.23, P > 0.05	F2, 24 = 0.73, P > 0.05	F2, 24 = 3.49, P > 0.05
TP (g/dl)	Female	6.98 ± 0.23^A	7.06 ± 0.10^A	7.28 ± 0.10^A	F1, 24 = 3.03, P > 0.05	F2, 24 = 5.72, P < 0.01	F2, 24 = 1.16, P > 0.05
TP (g/dl)	Male	6.96 ± 0.21^A	7.30 ± 0.17^AB	7.76 ± 0.12^B*	F1, 24 = 3.03, P > 0.05	F2, 24 = 5.72, P < 0.01	F2, 24 = 1.16, P > 0.05
Alb (g/dl)	Female	5.14 ± 0.19^A	4.54 ± 0.20^A	5.16 ± 0.31^A	F1, 24 = 0.019, P > 0.05	F2, 24 = 3.32, P > 0.05	F2, 24 = 0.17, P > 0.05
Alb (g/dl)	Male	4.94 ± 0.30^A	4.55 ± 0.19^A	5.26 ± 0.37^A	F1, 24 = 0.019, P > 0.05	F2, 24 = 3.32, P > 0.05	F2, 24 = 0.17, P > 0.05
Glucose (mg/dl)	Female	108.60 ± 5.28^A	101.00 ± 7.26^A	111.60 ± 9.97^A	F1, 24 = 18.11, P < 0.001	F2, 24 = 5.82, P < 0.01	F2, 24 = 4.17, P < 0.05
Glucose (mg/dl)	Male	173.60 ± 8.48^B*	116.60 ± 9.61^A	130.60 ± 14.26^A	F1, 24 = 18.11, P < 0.001	F2, 24 = 5.82, P < 0.01	F2, 24 = 4.17, P < 0.05
Urea (mg/dl)	Female	42.22 ± 2.07^A	39.82 ± 3.44^A	41.40 ± 2.82^A	F1, 24 = 10.84, P < 0.01	F2, 24 = 0.65, P > 0.05	F2, 24 = 0.33, P > 0.05
Urea (mg/dl)	Male	34.20 ± 0.96^A*	33.48 ± 1.06^A	37.12 ± 2.45^A	F1, 24 = 10.84, P < 0.01	F2, 24 = 0.65, P > 0.05	F2, 24 = 0.33, P > 0.05
Creatinine	Female	0.60 ± 0.04^AB	0.48 ± 0.04^A	0.66 ± 0.07^B	F1, 24 = 15.78, P < 0.01	F2, 24 = 1.07, P > 0.05	F2, 24 = 7.48, P < 0.01
Creatinine	Male	0.64 ± 0.04^A	0.86 ± 0.05^B*	0.72 ± 0.04^A	F1, 24 = 15.78, P < 0.01	F2, 24 = 1.07, P > 0.05	F2, 24 = 7.48, P < 0.01
ALP (U/L)	Female	69.50 ± 3.93^A	64.40 ± 5.26^A	142.00 ± 10.36^B	F1, 24 = 8.45, P < 0.01	F2, 24 = 21.33, P < 0.001	F2, 24 = 31.39, P < 0.001
ALP (U/L)	Male	133.40 ± 6.23^B*	90.10 ± 3.48^A*	100.40 ± 8.44^A*	F1, 24 = 8.45, P < 0.01	F2, 24 = 21.33, P < 0.001	F2, 24 = 31.39, P < 0.001
AST (U/L)	Female	159.20 ± 13.47^A	245.40 ± 10.62^B	177.00 ± 16.87^A	F1, 24 = 0.71, P > 0.05	F2, 24 = 40.34, P < 0.001	F2, 24 = 3.28, P > 0.05
AST (U/L)	Male	116.00 ± 7.60^A*	247.20 ± 3.57^C	193.40 ± 15.30^B	F1, 24 = 0.71, P > 0.05	F2, 24 = 40.34, P < 0.001	F2, 24 = 3.28, P > 0.05
ALT (U/L)	Female	34.00 ± 3.51^A	32.40 ± 3.54^A	48.40 ± 5.84^B	F1, 24 = 0.32, P > 0.05	F2, 24 = 2.34, P > 0.05	F2, 24 = 1.92, P > 0.05
ALT (U/L)	Male	39.40 ± 3.14^A	40.50 ± 3.61^A	40.80 ± 5.31^A	F1, 24 = 0.32, P > 0.05	F2, 24 = 2.34, P > 0.05	F2, 24 = 1.92, P > 0.05
LDH	Female	1498.60 ± 50.03^A	3436.80 ± 263.30^B	4049.00 ± 160.87^C	F1, 24 = 10.15, P < 0.01	F2, 24 = 97.08, P < 0.001	F2, 24 = 32.94, P < 0.001
LDH	Male	1214.40 ± 18.58^A*	4348.00 ± 215.41^C*	1979.00 ± 246.04^B*	F1, 24 = 10.15, P < 0.01	F2, 24 = 97.08, P < 0.001	F2, 24 = 32.94, P < 0.001
Ca (mg/dl)	Female	11.78 ± 0.10^A	11.68 ± 0.22^A	11.72 ± 0.26^A	F1, 24 = 14.73, P < 0.01	F2, 24 = 3.19, P > 0.05	F2, 24 = 2.72, P > 0.05
Ca (mg/dl)	Male	11.50 ± 0.19^B	11.22 ± 0.23^B	10.54 ± 0.19^A*	F1, 24 = 14.73, P < 0.01	F2, 24 = 3.19, P > 0.05	F2, 24 = 2.72, P > 0.05
Ph (mg/dl)	Female	4.55 ± 0.21^A	5.74 ± 0.74^A	4.36 ± 0.52^A	F1, 24 = 0.13, P > 0.05	F2, 24 = 2.44, P > 0.05	F2, 24 = 0.28, P > 0.05
Ph (mg/dl)	Male	4.74 ± 0.44^A	5.16 ± 0.62^A	4.29 ± 0.46^A	F1, 24 = 0.13, P > 0.05	F2, 24 = 2.44, P > 0.05	F2, 24 = 0.28, P > 0.05

* Represents significant differences (P < 0.05) in comparison to the corresponding female groups. In each row, the mean values marked with the same superscript letter are similar (insignificant, P > 0.05) whereas those with different ones are significantly differed (P < 0.05). P > 0.05: insignificant, P < 0.05, P < 0.01 and P < 0.001: significant effect at α = 0.05, 0.01, and 0.001, respectively

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