Protective effect of theaflavin on glycoprotein components and TCA cycle enzymes in high-fat diet and streptozotocin-induced diabetic rats

The Journal of Basic and Applied Zoology

Table 3 Effects of theaflavin on glycoprotein metabolism in control and experimental animals

Parameters	Control	Normal+ theaflavin (100 mg/kg b.wt)	Diabetes	Diabetes + theaflavin (100 mg/kg b.wt)	Diabetes + metformin (500 mg/kg)
Plasma (mg/dl)
Hexose	86.09 ± 5.88	84.47 ± 5.80	137.56 ± 10.24^b	91.47 ± 5.53^c	89.35 ± 5.81
Hexosamine	70.47 ± 6.99	68.58 ± 7.03	99.34 ± 10.68^b	80.68 ± 8.01^c	78.59 ± 9.18
Fucose	29.43 ± 2.50	27.30 ± 2.42	42.44 ± 4.26^b	32.39 ± 3.14^c	30.74 ± 2.93
Sialic acid	52.26 ± 4.89	50.56 ± 4.92	73.51 ± 6.00^b	59.64 ± 5.60^c	58.10 ± 5.69
Liver (mg/g)
Hexose	29.28 ± 2.61	28.59 ± 2.51	52.49 ± 5.09^b	32.13 ± 3.21^c	30. 77 ± 2.97
Hexosamine	13.55 ± 1.37	12. 48 ± 1.29	33.48 ± 2.95^b	18.56 ± 1.61^c	17.17 ± 1.46
Fucose	19.36 ± 1.84	20.43 ± 1.78	37.53 ± 3.59^b	24.27 ± 2.47^c	22.99 ± 2.26
Sialic acid	11.47 ± 1.04	10.81 ± 1.09	4.80 ± 0.45b	9.02 ± 0.85c	8.26 ± 0.81
Kidney (mg/g)
Hexose	22.36 ± 2.19	21.60 ± 2.01	41.87 ± 2.89^b	25.55 ± 2.44^c	24.10 ± 2.22
Hexosamine	18.79 ± 1.35	17.70 ± 1.53	38.73 ± 2.32^b	22.58 ± 1.63^c	21.74 ± 1.59
Fucose	14.53 ± 1.34	13.53 ± 1.37	27.63 ± 2.16^b	17.86 ± 1.66^c	16.55 ± 1.86
Sialic acid	7.53 ± 0.61	6.85 ± 0.67	3.89 ± 0.36^b	5.80 ± 0.56^c	5.27 ± 0.63

Values are given as mean ± SD for six animals in each group
Values are considered significantly different at P < 0.05 with post-hoc LSD test *P < 0.05
^aControl vs. drug control (theaflavin-alone-treated rats
^bControl rats. vs. diabetic rats
^cDiabetic rats vs. theaflavin (100 mg/kg)
^dDiabetic rats treated with theaflavin 100 mg/kg vs. metformin (500 mg/kg