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Table 4 Effects of theaflavin on TCA cycle enzymes in control and experimental animals

From: Protective effect of theaflavin on glycoprotein components and TCA cycle enzymes in high-fat diet and streptozotocin-induced diabetic rats

Parameters

Control

Normal+ theaflavin (100 mg/kg b.wt)

Diabetes

Diabetes + theaflavin (100 mg/kg b.wt)

Diabetes + metformin (500 mg/kg b.wt)

Liver

 Isocitrate dehydrogenase

682.75 ± 45.47

680.26 ± 45.57

371.44 ± 36.53b

612.37 ± 40.45c

610.66 ± 40.19

 Malate dehydrogenase

393.23 ± 40.16

389.99 ± 40.21

171.17 ± 22.40b

304.09 ± 27.48c

302.34 ± 27.67

 Alpha ketoglutarate dehydrogenase

284.35 ± 30.35

282.68 ± 20.76

104.5 ± 11.72b

200.28 ± 15.87c

198.37 ± 15.88

 Succinate dehydrogenase

56.39 ± 4.85

54.09 ± 5.20

14.60 ± 2.66b

36.16 ± 3.21c

34.51 ± 2.86

Kidney

 Isocitrate dehydrogenase

615.41 ± 24.55

612.79 ± 24.47

297.21 ± 17.51b

591.13 ± 22.11c

589.39 ± 22.02

 Malate dehydrogenase

323.44 ± 23.62

322.61 ± 22.90

116.51 ± 13.23b

283.32 ± 19.89c

281.56 ± 19.96

 Alpha ketoglutarate dehydrogenase

85.05 ± 6.39

82.25 ± 6.62

24.45 ± 3.61b

68.54 ± 6.06c

66.85 ± 6.05

 Succinate dehydrogenase

30.31 ± 2.70

28.29 ± 2.65

13.31 ± 1.18b

22.94 ± 2.44c

21.07 ± 2.43

  1. Values are given as mean ± SD for six animals in each group
  2. Values are considered significantly different at P < 0.05 with post-hoc LSD test *P < 0.05
  3. The enzyme activities are expressed as: n moles of a-ketoglutarate/h/mg of protein for isocitrate dehydrogenase, n moles of potassium ferrocyanide/h/mg of protein for α-ketoglutarate dehydrogenase, μmoles of succinate oxidized/min/mg of protein for succinate dehydrogenase, and μmoles of NADH oxidized/min/mg of protein for malate dehydrogenase
  4. aControl vs. drug control (theaflavin-alone-treated rats
  5. bControl rats vs. diabetic rats
  6. cDiabetic rats vs. theaflavin (100 mg/kg)
  7. dDiabetic rats treated with theaflavin (100 mg/kg) vs. metformin (500 mg/kg)