Fig. 4

Histopathological of the brain stained with hematoxylin and eosin in a control groups of rat showing normal arrangement of layers of neurons (blue arrow) and neuronal fibers (*); b cross-section of rat brain treated with l-carnitine (10 mg/kg) showing normal white matter with normal neurons (blue arrow) and neuronal fibers (*); c aspartame low dose group (75 mg/kg) showing moderate area of hemorrhage (*) and necrosis (***) in the brain; d aspartame high dose rats (150 mg/kg) showing large area of hemorrhage (*) and necrotic areas of the brain (***) with congested area (red arrow); e low dose of aspartame and l-carnitine-treated group showing very reduced congested area (*) with normal neural fibers (yellow arrow); f high dose of aspartame and l-carnitine showing the recovery of the congested area with moderate area of necrosis (black arrow) with normal appearance to fibers (**) and reduced necrotic neurons (× 400(