Skip to main content

Table 1 Effect of l-carnitine on antioxidant enzymes, glutathione and thiol level in the brain of male rats treated with aspartame

From: l-carnitine acts as a neuroprotecor against aspartame injury in Wistar albino rat

Parameters Control LC ASP-LD ASP-HD ASP-LD and LC ASP-HD and LC
MPO (nmol/min/mL) 26.6 ± 0.8 27.7 ± 0.8 36.9 ± 1.9a 38.5 ± 2.1a 30.0 ± 1.9b 32.0 ± 1.4b
XO (U/g tissue) 16.5 ± 0.8 16.2 ± 0.5 31.0 ± 1.8a 35.2 ± 1.6a 24.2 ± 1.5b 27.9 ± 0.9b
SOD (nmol/g tissue) 25.9 ± 0.9 26.1 ± 0.9 11.4 ± 0.5a 9.7 ± 0.8a 17.5 ± 1.3b 16.9 ± 0.9b
CAT (U/g tissue) 5.9 ± 0.1 6.2 ± 0.4 2.7 ± 0.2a 1.7 ± 0.4a 4.1 ± 0.2 3.6 ± 0.2
GPx (mol/g tissue) 20.81 ± 1.5 24.17 ± 1.6 13.34 ± 0.4a 12.34 ± 0.7a 17.65 ± 0.9b 15.78 ± 0.5b
Thiol (μmol/g tissue) 11.1 ± 1.1 11.8 ± 1.4 6.2 ± 1.0a 5.3 ± 1.1a 12.2 ± 1.6 10.1 ± 1.7
GSH (mol/g tissue) 15.9 ± 0.5 16.2 ± 0.5 9.5 ± 0.6a 9.8 ± 0.8a 13.5 ± 0.5b 13.1 ± 0.5b
  1. Values are expressed as means ± SE; n = 8 for each treatment group
  2. LCl-carnitine, ASP-LD a low dose of aspartame, ASP-HD high dose of aspartame, MPO myeloperoxidase, XO xanthine oxidase, SOD superoxide dismutase, CAT catalase, GPx glutathione peroxidase, GSH reduced glutathione
  3. aSignificant difference as compared to control
  4. bSignificant difference as compared to its relative group of ASP (P ≤ 0.05)