Fig. 2

Photomicrograph of cerebral cortex of mice. a Control group showing normal architecture of cells of cerebral cortex (Cc) with medulla (CM). × 200. b Cd group showing hyperemia (HY) in the cortex with vacuolation (V), lymphocytic infiltration (LI), and with the appearance of pyknotic cells (Pc). Protective Groups c Cd + GE group showed improvement in the nerve cells in many areas with little vacuolation (V) in the tissue. d Cd + TE-treated group, the cortex appeared to be normal with all the different types of cells having a compact nucleus in the neurophil. e Cd + GE + TE group showing normal cortex structure with pyramidal cells but some binucleated cells were also seen. Therapeutic Groups f Cd + GE-treated group, the pyramidal and granule cells were slightly affected with a dark-stained nucleus but mild shrinkage in the cells with a pericellular halo was visible. g Cd + TE group showed almost normal with pyramidal cells, granular cells, and neuroglial cells in the neurophil of the cortex with less pyknotic cells (Pc) and vacuolation (V). h Cd + GE + TE group, the cortex showed many normal cells with slight hyperemia of blood capillary and necrotic cells (Nc). Shrinkage was also seen in the cells with pericellular halos. × 400, H & E stain