Antinociceptive, antiinflammatory, and antipyretic effects induced by the venom of Egyptian scorpion Androctonus amoreuxi

The Journal of Basic and Applied Zoology

Table 1 Antipyretic effect of A. amoreuxi venom using Brewer’s yeast-induced pyrexia in rats

Rectal temperature (TR°C) at different time intervals (h)
Treatment	0 h	1st hour	2nd hour	3rd hour	4th hour	5th hour
Yeast control	38.05 ± 0.0671	38.05 ± 0.085	38.00 ± 0.077	38.00 ± 0.052	38.00 ± 0.063	38.07 ± 0.056
Yeast + 1/10 LD₅₀ (0.385 mg/kg) A. amoreuxi venom	38.04 ± 0.061	35.69 ± 0.128*	36.54 ± 0.318*	37.08 ± 0.157*	36.925 ± 0.170*	37.09 ± 0.340*
Yeast + 1/5 LD₅₀ (0.77 mg/kg) A. amoreuxi venom	38.09 ± 0.051	35.55 ± 0.159*	36.08 ± 0.364*	36.25 ± 0.194*	36.93 ± 0.330*	37.03 ± 0.33*
Yeast + metamizol (5 mg/kg)	38.01 ± 0.055	36.85 ± 0.146*^#	36.30 ± 0.168*^#	36.25 ± 0.199*^#	36.43 ± 0.067*^#	36.80 ± 0.207*^#

Data are presented as mean ± SEM (6 animals /group)
*A significant difference between yeast control and treated groups using Student’s unpaired t test (p < 0.05)
^#A significant difference between all groups at time intervals using one-way ANOVA (p ≤ 0.05)