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Table 3 Antiinflammatory effect of A. amoreuxi venom using carrageenan-induced paw edema in mice

From: Antinociceptive, antiinflammatory, and antipyretic effects induced by the venom of Egyptian scorpion Androctonus amoreuxi

Treatment Paw thickness (cm)
0 hour 1st hour 2nd hour 3rd hour 4th hour 5th hour
Normal control 0.012 ± 0.011 0.005 ± 0.008 0.012 ± 0.011 0.005 ± 0.008 0.005 ± 0.008 0.012 ± 0.011
Carrageenan control 0.005 ± 0.008 0.100 ± 0.041 0.163 ± 0.014 0.15 ± 0.011 0.138 ± 0.009 0.138 ± 0.009
Carrageenan + 1/5 LD50
A. amoreuxi venom
0.005 ± 0.008 0.131 ± 0.055 0.094 ± 0.040*
(42.33)
0.081 ± 0.035*
(46.0)
0.056 ± 0.026*
(59.42)
0.038 ± 0.010*
(72.46)
Carrageenan + diclofenac sodium (20 mg/kg) 0.012 ± 0.011 0.081 ± 0.032*
(19.0)
0.100 ± 0.043*#
(38.65)
0.094 ± 0.038*#
(37.33)
0.094 ± 0.038*#
(31.88)
0.088 ± 0.035*#
(36.23)
  1. Data are presented as mean ± SEM (6 animals/group)
  2. *A significant difference between carrageenan control and each treated group using Student’s unpaired t test (p < 0.05)
  3. #A significant difference between all groups at time intervals using one-way ANOVA (p ≤ 0.05). Values between brackets represent percentage of inflammation inhibition. ∆ Paw thickness (cm) = Paw thickness at each time interval − paw thickness at 0 h)