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Table 3 Antiinflammatory effect of A. amoreuxi venom using carrageenan-induced paw edema in mice

From: Antinociceptive, antiinflammatory, and antipyretic effects induced by the venom of Egyptian scorpion Androctonus amoreuxi

Treatment

Paw thickness (cm)

0 hour

1st hour

2nd hour

3rd hour

4th hour

5th hour

Normal control

0.012 ± 0.011

0.005 ± 0.008

0.012 ± 0.011

0.005 ± 0.008

0.005 ± 0.008

0.012 ± 0.011

Carrageenan control

0.005 ± 0.008

0.100 ± 0.041

0.163 ± 0.014

0.15 ± 0.011

0.138 ± 0.009

0.138 ± 0.009

Carrageenan + 1/5 LD50

A. amoreuxi venom

0.005 ± 0.008

0.131 ± 0.055

0.094 ± 0.040*

(42.33)

0.081 ± 0.035*

(46.0)

0.056 ± 0.026*

(59.42)

0.038 ± 0.010*

(72.46)

Carrageenan + diclofenac sodium (20 mg/kg)

0.012 ± 0.011

0.081 ± 0.032*

(19.0)

0.100 ± 0.043*#

(38.65)

0.094 ± 0.038*#

(37.33)

0.094 ± 0.038*#

(31.88)

0.088 ± 0.035*#

(36.23)

  1. Data are presented as mean ± SEM (6 animals/group)
  2. *A significant difference between carrageenan control and each treated group using Student’s unpaired t test (p < 0.05)
  3. #A significant difference between all groups at time intervals using one-way ANOVA (p ≤ 0.05). Values between brackets represent percentage of inflammation inhibition. ∆ Paw thickness (cm) = Paw thickness at each time interval − paw thickness at 0 h)