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Fig. 4 | The Journal of Basic and Applied Zoology

Fig. 4

From: Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

Fig. 4

a Nizatidine treated group for 2 weeks showed changes in parietal cells with low eosinophilic cytoplasm and low basophilic nucleus, with moderate infiltration of inflammatory cells and mild erosive luminal surface, gastric gland showed mild degenerative changes (H&E,X40). b Nizatidine group treated for 3 weeks showed changes of parietal cells with pale eosinophilic cytoplasm and pale basophilic and karyolyed nuclei, marked infiltration of inflammatory cells, the luminal surface showed marked ulcerative changes with surface epithelium degeneration (H&E, X40). c Ranitidine prophylactic group showed normal distribution of parietal cells (PC) with eosinophilic cytoplasm and basophilic nuclei, degenerative changes of surface epithelium (SE) and mild infiltration of inflammatory cells (IFC), with ulcerative luminal surface (PU) (H&E, X40). d Ranitidine group treated for 2 weeks showed changes of parietal cells with low eosinophilic cytoplasm and low basophilic nuclei, degenerative changes of surface epithelium. With karyolysis, the luminal surface showed mild ulcerative and marked erosive changes (H&E, X40). e Ranitidine-treated group for 3 weeks showed changes of parietal cells with marked eosinophilic cytoplasm and marked basophilic nucleus, mild infiltration of inflammatory cells (IFC) with mild erosive changes at the luminal surface, normal structure of gastric glands (H&E, X40)

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