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Table 1 Effects of oral administration of nizatidine and ranitidine (27 mg/kg b. wt.) on ulceration in rats administrated NSAIDs (piroxicam (5 mg/kg) followed 60 min later by paracetamol (80 mg/kg) as single dosage)

From: Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

Parameters Positive control group (n = 5) Group received ranitidine (n = 5) Group received nizatidine (n = 5) p
Ulceration percent (%)
• 1 week before 100 100 80 0.34
• 2 week after 100 80 80 0.56
• 3 weeks after 100 60 40 0.12
• 4 weeks after 100 40a 20a,b 0.03*
Mean ulcer score
• 1 week before 4 ± 0.4 2 ± 0.2a 2 ± 0.4a < 0.0001*
• 2 week after 4 ± 0.4 2 ± 0.2 a 2 ± 0.1a < 0.0001*
• 3 weeks after 4 ± 0.4 1 ± 0.3 a 1 ± 0.3a < 0.0001*
• 4 weeks after 4 ± 0.4 1 ± 0.3 a 1 ± 0.3a < 0.0001*
Ulcer index
• 1 week before 400 ± 22 200 ± 11.2a 160 ± 32.1a,b < 0.0001*
• 2 week after 400 ± 22 140 ± 23.7a 160 ± 26.5a < 0.0001*
• 3 weeks after 400 ± 22 60 ± 14.9a 40 ± 13.4a < 0.0001*
• 4 weeks after 400 ± 22 40 ± 10.6a 20 ± 9.6a,b < 0.0001*
Preventive index (%)
• 1 week before 0 50a 60a < 0.0001*
• 2 week after 0 40a 60a,b < 0.0001*
• 3 weeks after 0 85a 90a < 0.0001*
• 4 weeks after 0 90a 95a < 0.0001*
  1. Data presented as mean ± SEM or percentage
  2. p one-way ANOVA significance
  3. Tukey’s honestly significant difference (Tukey’s HSD) test
  4. aSignificant difference compared to positive control
  5. bSignificant difference compared to group received ranitidine
  6. * means significant p<l0.05