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Table 2 Effects of oral administration of nizatidine, ranitidine (27 mg/kg b. wt.) on serum hormones of male albino rats

From: Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

Parameters

Positive control group (n = 5)

Group received ranitidine (n = 5)

Group received nizatidine (n = 5)

p

Serum FSH (ng/mL)

• 2 week after

0.75 ± 0.07

1.38 ± 0.14a

1.8 ± 0.07a,b

< 0.0001*

• 3 weeks after

0.76 ± 0.07

2.83 ± 0.31a

2.08 ± 0.13a,b

< 0.0001*

• 4 weeks after

0.73 ± 0.07

3.18 ± 0.22a

3.5 ± 0.27a

< 0.0001*

Serum LH (pg/mL)

• 2 week after

0.73 ± 0.06

1.11 ± 0.12a

1.34 ± 0.05a,b

< 0.0001*

• 3 weeks after

0.7 ± 0.06

1.71 ± 0.2a

1.38 ± 0.07a

< 0.0001*

• 4 weeks after

0.71 ± 0.06

2.12 ± 0.23a

2.34 ± 0.13a

< 0.0001*

Serum prolactin (ng/mL)

• 2 week after

2.68 ± 0.12

2.88 ± 0.26

3.3 ± 0.25a,b

< 0.0001*

• 3 weeks after

2.53 ± 0.12

3.62 ± 0.33a

2.9 ± 0.2a,b

< 0.0001*

• 4 weeks after

2.34 ± 0.12

3.74 ± 0.22a

3.5 ± 0.18a

< 0.0001*

Serum total testosterone (ng/mL)

• 2 week after

2.45 ± 0.11

1.32 ± 0.1a

1.25 ± 0.19a

< 0.0001*

• 3 weeks after

2.25 ± 0.11

1.06 ± 0.13a

1.28 ± 0.23a

< 0.0001*

• 4 weeks after

2.15 ± 0.11

0.76 ± 0.05a

0.92 ± 0.05a,b

< 0.0001*

Serum-free testosterone (pg/mL)

• 2 week after

11.54 ± 0.71

9.08 ± 0.32a

9.06 ± 0.22a

< 0.0001*

• 3 weeks after

11.34 ± 0.71

8.86 ± 0.44a

8.84 ± 0.38a

< 0.0001*

• 4 weeks after

10.44 ± 0.71

6.84 ± 0.51a

7.42 ± 0.26a

< 0.0001*

  1. Data presented as mean ± SEM
  2. p one-way ANOVA significance
  3. Tukey’s honestly significant difference (Tukey’s HSD) test
  4. aSignificant difference compared to positive control
  5. bSignificant difference compared to group received ranitidine