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Table 2 Effects of oral administration of nizatidine, ranitidine (27 mg/kg b. wt.) on serum hormones of male albino rats

From: Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

Parameters Positive control group (n = 5) Group received ranitidine (n = 5) Group received nizatidine (n = 5) p
Serum FSH (ng/mL)
• 2 week after 0.75 ± 0.07 1.38 ± 0.14a 1.8 ± 0.07a,b < 0.0001*
• 3 weeks after 0.76 ± 0.07 2.83 ± 0.31a 2.08 ± 0.13a,b < 0.0001*
• 4 weeks after 0.73 ± 0.07 3.18 ± 0.22a 3.5 ± 0.27a < 0.0001*
Serum LH (pg/mL)
• 2 week after 0.73 ± 0.06 1.11 ± 0.12a 1.34 ± 0.05a,b < 0.0001*
• 3 weeks after 0.7 ± 0.06 1.71 ± 0.2a 1.38 ± 0.07a < 0.0001*
• 4 weeks after 0.71 ± 0.06 2.12 ± 0.23a 2.34 ± 0.13a < 0.0001*
Serum prolactin (ng/mL)
• 2 week after 2.68 ± 0.12 2.88 ± 0.26 3.3 ± 0.25a,b < 0.0001*
• 3 weeks after 2.53 ± 0.12 3.62 ± 0.33a 2.9 ± 0.2a,b < 0.0001*
• 4 weeks after 2.34 ± 0.12 3.74 ± 0.22a 3.5 ± 0.18a < 0.0001*
Serum total testosterone (ng/mL)
• 2 week after 2.45 ± 0.11 1.32 ± 0.1a 1.25 ± 0.19a < 0.0001*
• 3 weeks after 2.25 ± 0.11 1.06 ± 0.13a 1.28 ± 0.23a < 0.0001*
• 4 weeks after 2.15 ± 0.11 0.76 ± 0.05a 0.92 ± 0.05a,b < 0.0001*
Serum-free testosterone (pg/mL)
• 2 week after 11.54 ± 0.71 9.08 ± 0.32a 9.06 ± 0.22a < 0.0001*
• 3 weeks after 11.34 ± 0.71 8.86 ± 0.44a 8.84 ± 0.38a < 0.0001*
• 4 weeks after 10.44 ± 0.71 6.84 ± 0.51a 7.42 ± 0.26a < 0.0001*
  1. Data presented as mean ± SEM
  2. p one-way ANOVA significance
  3. Tukey’s honestly significant difference (Tukey’s HSD) test
  4. aSignificant difference compared to positive control
  5. bSignificant difference compared to group received ranitidine