Fig. 1

Photomacrograph GD 20 fetal rat shows the external morphology. a Control group displayed normal morphology. b–g Fetus maternally treated with low-dose of progesterone (1.8 mg/200 g bw), b fetus with acromelia in the forelimb (white arrow), e fetus exhibited leptocephaly (LP) and sclerosis, c runt fetus, d and f hindlimb displayed symmelia (white arrow head). f Fetus with acromelia in hind limb white arrow head). h–j Fetus maternally treated with high dose of progesterone (3.6 mg/200 g bw), h Fetus revealed acromelia in the forelimb (white arrow), i runt fetus with kinked tail (T) and j fetus with cutis lesion. Scale bar=1 cm