Fig. 5
From: Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats
a The fetal rat testis of the control group shows a normal architecture for the seminiferous tubules (SE) and interstitial tissue (IT). b The fetuses maternally treated with low-dose progesterone (1.8 mg/200 g bw) showed degenerated seminiferous tubules (black arrow). c The fetuses maternally treated with high-dose progesterone (3.6 mg/200 g bw) show hemorrhage between the seminiferous tubules (black arrowhead) and congested blood vessels (CO), and most seminiferous tubules have an irregular degenerate (DT) pattern. d The ovary of the control has a normal architecture of well-developed primordial follicles (white arrow). e The fetuses maternally treated with low-dose progesterone show incomplete development of their sex cords into primordial follicles with mildly degenerated sex cords (white arrowhead) that exhibit hydropic degeneration of the epithelial tissue. f The fetuses maternally treated with high-dose progesterone show poorly developed ovaries with an atrophied sex cord (star). a The fetal rat cartilage of the control group has a normal chondrocyte. b The cartilage of the group maternally treated with low-dose progesterone shows normal cartilage histology. c The fetal rat cartilage maternally treated with high-dose progesterone shows hypertrophied chondrocytes (asterisks)