From: Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats
Parameters | Control | Low dose, 1.8 mg/200 g bw | High dose, 3.6 mg/200 g bw |
---|---|---|---|
No. of dams | 9 | 9 | 9 |
No. of fetus/dam | 61 | 62 | 60 |
No. of dams had abnormal fetus | 7/9 | 9/9 | 9/9 |
Anasarca | 0.01±0.00c (0.11%±0.00) | 0.44±0.17b (7.40%±2.92) | 1.88±0.11a (31.90%±2.33) |
Runt (small) | 0.22±0.14b (3.17% ± 2.1) | 4.00±0.33a (64.02%±4.78) | 5.00±0.40ac (82.59%±3.95) |
Hematoma | 0.22±0.14c (3.70 % ± 2.45) | 3.77±0.27b (60.85%±4.63) | 4.66±0.28a (77.57%±2.80) |
Cutis lesion | 0.01±0.00b (0.11%±0.00) | 0.66±0.16b (0.10%±0.02) | 0.88±0.11a (15.03%±1.99) |
Symmelia (bent limb) | 0.02±0.00c (0.22%±0.00) | 0.66±0.16b (10.58%±2.66) | 2.44±0.17a (40.63%±2.19) |
Acromelia (short limb) | 0.01±0.00c (0.11%±0.00) | 0.77±0.14b (0.12%±0.02) | 2.00±0.00a (33.76%±1.35) |
Kinked tail | 0.01±0.00c (0.11%±0.00) | 0.77±0.14b (00.12%±0.02) | 2.44±0.17a (40.63%±2.19) |
Large genital tubercle | 0.02±0.00b (0.22%±0.00) | 0.77±0.27b (10.60%±4.74) | 2.33±0.28a (38.78%±4.39) |
Decreased anogenital distance | 0.02±0.00c (0.22%±0.00) | 1.55±0.37b (25.40%±6.38) | 3.88±0.45a (62.17%±6.90) |