Skip to main content

Table 3 Incidence of morphological anomalies in the control fetuses and fetuses maternally treated with low and high doses of progesterone

From: Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats

Parameters Control Low dose, 1.8 mg/200 g bw High dose, 3.6 mg/200 g bw
No. of dams 9 9 9
No. of fetus/dam 61 62 60
No. of dams had abnormal fetus 7/9 9/9 9/9
Anasarca 0.01±0.00c (0.11%±0.00) 0.44±0.17b (7.40%±2.92) 1.88±0.11a (31.90%±2.33)
Runt (small) 0.22±0.14b (3.17% ± 2.1) 4.00±0.33a (64.02%±4.78) 5.00±0.40ac (82.59%±3.95)
Hematoma 0.22±0.14c (3.70 % ± 2.45) 3.77±0.27b (60.85%±4.63) 4.66±0.28a (77.57%±2.80)
Cutis lesion 0.01±0.00b (0.11%±0.00) 0.66±0.16b (0.10%±0.02) 0.88±0.11a (15.03%±1.99)
Symmelia (bent limb) 0.02±0.00c (0.22%±0.00) 0.66±0.16b (10.58%±2.66) 2.44±0.17a (40.63%±2.19)
Acromelia (short limb) 0.01±0.00c (0.11%±0.00) 0.77±0.14b (0.12%±0.02) 2.00±0.00a (33.76%±1.35)
Kinked tail 0.01±0.00c (0.11%±0.00) 0.77±0.14b (00.12%±0.02) 2.44±0.17a (40.63%±2.19)
Large genital tubercle 0.02±0.00b (0.22%±0.00) 0.77±0.27b (10.60%±4.74) 2.33±0.28a (38.78%±4.39)
Decreased anogenital distance 0.02±0.00c (0.22%±0.00) 1.55±0.37b (25.40%±6.38) 3.88±0.45a (62.17%±6.90)
  1. Data was expressed as mean ± SE and mean percent.
  2. Different superscripts in the same row indicates significance at P< 0.001