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Table 3 Incidence of morphological anomalies in the control fetuses and fetuses maternally treated with low and high doses of progesterone

From: Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats

Parameters

Control

Low dose, 1.8 mg/200 g bw

High dose, 3.6 mg/200 g bw

No. of dams

9

9

9

No. of fetus/dam

61

62

60

No. of dams had abnormal fetus

7/9

9/9

9/9

Anasarca

0.01±0.00c (0.11%±0.00)

0.44±0.17b (7.40%±2.92)

1.88±0.11a (31.90%±2.33)

Runt (small)

0.22±0.14b (3.17% ± 2.1)

4.00±0.33a (64.02%±4.78)

5.00±0.40ac (82.59%±3.95)

Hematoma

0.22±0.14c (3.70 % ± 2.45)

3.77±0.27b (60.85%±4.63)

4.66±0.28a (77.57%±2.80)

Cutis lesion

0.01±0.00b (0.11%±0.00)

0.66±0.16b (0.10%±0.02)

0.88±0.11a (15.03%±1.99)

Symmelia (bent limb)

0.02±0.00c (0.22%±0.00)

0.66±0.16b (10.58%±2.66)

2.44±0.17a (40.63%±2.19)

Acromelia (short limb)

0.01±0.00c (0.11%±0.00)

0.77±0.14b (0.12%±0.02)

2.00±0.00a (33.76%±1.35)

Kinked tail

0.01±0.00c (0.11%±0.00)

0.77±0.14b (00.12%±0.02)

2.44±0.17a (40.63%±2.19)

Large genital tubercle

0.02±0.00b (0.22%±0.00)

0.77±0.27b (10.60%±4.74)

2.33±0.28a (38.78%±4.39)

Decreased anogenital distance

0.02±0.00c (0.22%±0.00)

1.55±0.37b (25.40%±6.38)

3.88±0.45a (62.17%±6.90)

  1. Data was expressed as mean ± SE and mean percent.
  2. Different superscripts in the same row indicates significance at P< 0.001