Table 4 Incidence of skeletal anomalies in the control fetuses and fetuses maternally treated with low and high doses of progesterone

Lordosis

0.01±0.00^c (0.11%±0.00)

0.88±0.11^b (14.29%±1.81)

2.77±0.14^a (46.93%±3.27)

Vertebral unossified area

0.22±0.14^c (3.17% ± 2.10)

0.88±0.11^b (14.29%±1.81)

3.55±0.24^a (60.11%±5.02)

Skull roof incomplete

0.02±0.00^c (0.22%±0.00)

1.22±0.14^b (19.31%±1.75)

3.44±0.17^a (57.51%±2.20)

Incomplete ossification of sternebrae

0.01±0.00^c (0.11%±0.00)

1.11±0.20^b (17.99%±3.39)

3.11±0.26^a (53.23%±6.05)

Hemisternebra (s)

0.22±0.14^c (3.17%±2.10)

0.66±0.16^b (10.58%±2.66)

1.88±0.11^a (31.90%±2.33)

Incomplete ossification of vertebrae

0.01±0.00^c (0.11%±0.00)

1.11±0.11^b (17.99%±1.94)

2.88±0.35^a (47.51%±4.76)

Incomplete ossification of scapula

0.02±0.00^c (0.22%±0.00)

0.88±0.11^b (14.29%±1.81)

2.55±0.17^a (42.49%±2.20)

Incomplete ossification of humerus

0.02±0.00^c (0.22%±0.00)

1.11±0.20^b (17.46%±2.77)

2.55±0.17^a (42.49%±2.20)

Incomplete ossification of radius and ulna

0.01±0.00^c (0.11%±0.00)

1.33±0.23^b (21.16%±3.60)

2.55±0.17^a (42.49%±2.20)

Incomplete ossification of carpal

0.02±0.00^b (0.22%±0.00)

0.77±0.27^b (12.43%±4.59)

2.22±0.40^a (36.19%±6.10)

Incomplete ossified metacarpal

0.01±0.00^c (0.11%±0.00)

1.44±0.17^b (23.54%±3.11)

3.11±0.11^a (52.49%±2.69)

Forelimb aphalangia (absent phalanx)

0.01±0.00^a (0.11%±0.00)

0.66±0.28^a (11.11%±4.81)

0.66±0.44^a (11.11%±7.34)

Forelimb incomplete ossification of phalanges

0.02±0.00^c (0.22%±0.00)

2.44±0.17^a (39.68%±3.32)

3.11±0.26^ab (51.75%±3.92)

Femur incomplete ossification

0.02±0.00^c (0.22%±0.00)

1.33±0.16^b (21.69%±2.92)

3.00±0.00^a (50.63%±2.03)

Tibia and fibula incomplete ossification (O)

0.01±0.00^b (0.11%±0.00)

1.33±0.16^a (21.69%±2.92)

1.66±0.23^ac (27.46%±3.58)

Incomplete ossification of tarsal

0.02±0.00^b (0.22%±0.00)

0.55±0.17^b (9.25%±2.92)

2.77±0.32^a (46.19%±5.05)

Incomplete ossified metatarsal

0.22±0.14^c (3.70%±2.45)

1.22±0.14^b (19.31%±1.75)

3.66±0.23^a (61.22%±3.40)

Hindlimb aphalangia (absent phalanx)

0.01±0.00^b (0.11%±0.00)

2.22±0.14^b (3.70%±2.45)

2.33±0.52^a (38.78%±8.56)

Hindlimb incomplete ossification of phalanges

0.22±0.14^b (3.70%±2.45)

1.77±0.36^a (28.57%±6.03)

3.00±0.60^ac (50.00%±9.83)