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Fig. 3 | The Journal of Basic and Applied Zoology

Fig. 3

From: Cisplatin-induced neurotoxicity in cerebellar cortex of male mice involves oxidative stress and histopathology

Fig. 3

af Light micrograph of sections of the cerebellar cortex of the cerebellum. a Control mice showing the folium (arrows) of the gray matter. H&E, × 100 (bar = 200 μm). b Semithin section showing the flask-shaped of Purkinje cells (P). Toluidine blue, × 1000 (bar = 20 μm). c Mice intraperitoneally injected with 5 mg/kg bw cisplatin showing shrunken Purkinje cells (P) and halo of empty spaces around the Purkinje cells (arrows), × 400 (bar = 50 μm). d The nuclei of some Purkinje cells (P) are hardly identified. Note the dense nuclei of the granular cells (arrows). Toluidine blue, × 1000 (bar = 20 μm). e Mice treated with 10 mg/kg bw cisplatin showing deposition of the Purkinje cells (P) surrounded by a highly vacuolated cytoplasm (arrow), × 400 (bar = 50 μm). f Disorganization of the Purkinje cells with hardly identified nuclei (arrows). Toluidine blue, × 1000 (bar = 20 μm)

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