Ameliorative activity of medicinal plant fraction for neuroprotection against acrylamide-induced neurotoxicity in Drosophila melanogaster—a comparative study

The Journal of Basic and Applied Zoology

Table 1 Modulatory effect of OLE-2 and CU-3 plant fractions on antioxidant enzyme activities in the head of adult male D. melanogaster co-exposed with acrylamide (ACR) at the end of 7 days

Assays	Control	ACR	ACR + OLE-2 (0.2% w/v)	ACR + OLE-2 (0.4%w/v)	ACR + OLE-2 (0.6% w/v)	ACR + CU-3 (0.2%w/v)	ACR + CU-3 (0.4%w/v)	ACR + CU-3 (0.6% w/v)
LPO^a	4.94 ± 0.691	6.16 ± 0.152	6.10 ± 0.100	5.57 ± 0.315	5.67 ± 0.050	5.73 ± 0.115	5.20 ± 0.005	5.14 ± 0.112
Catalase^b	13.7 ± 0.173	15.6 ± 0.208	14.21 ± 0.037	12.67 ± 0.301	7.59 ± 0.353	15.25 ± 0.015	13.52 ± 0.205	11.63 ± 1.479
AChE^c	124.6 ± 6.429	162.6 ± 2.081	150.6 ± 2.309	149 ± 1	145.6 ± 0.577	153.6 ± 2.081	151.6 ± 0.577	149 ± 1

Data analysed by one-way ANOVA followed by Tukey’s test for comparison of control, ACR (8 mM) and co-exposed with ACR + plant fractions at different concentrations Mean ± SD
^aLipid peroxidation (LPO), MDA nM/mg protein
^bCatalase, nmol of H₂O₂/min/mg protein
^cAChE, nM/min/mg protein