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Fig. 1 | The Journal of Basic and Applied Zoology

Fig. 1

From: Protective effects of some antioxidants against long-term intake of aspartame toxicity on liver and kidney: biochemical and histopathological approach in rats

Fig. 1

Photomicrographs of liver section from male and female rats, respectively, of A control groups showing normal hepatocytes arranged in hepatic cords (hc) with the presence of blood vessel (bv) and bile canal (arrow) in portal area ( × 10 × 40); B rats from groups treated with aspartame showing vasculitis (v) in hepatic blood vessels with the presence of mixed thrombus and degeneration (t) of endothelial cell lining blood vessel ( × 10 × 40); C rats from groups treated with aspartame showing hepatic edema (e) with dilatation of Disse spaces and activation of Kupffer cells (kc) ( × 10 × 40); D rats from groups treated with aspartame and garlic showing hepatocellular degeneration (d) ( × 10 × 40);  E rats from group treated with aspartame and melatonin showing hepatic edema (e) with dilatation of central vein (cv) and Disse space ( × 10 × 40);  F rats from groups treated with aspartame and thymoquinone showing congestion (c)in the portal area with inflammatory cell reaction (arrow) ( × 10 × 40);   andG rats from groups treated with aspartame and melatonin plus thymoquinone showing more or less normal hepatic structure ( × 10 × 10)

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