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Table 1 Effect of BPF (2.314 mg/kg b.w) and Levothyroxine (100 μg/kg b.w) on serum T4, T3, Ft4, Ft3 and TSH levels of male albino rats induced by carbimazole (0.05 mg/kg b.w) for 60 days in different groups

From: Effect of a bradykinin potentiating factor separated from honey bee venom on thyroid gland and testis in hypothyroid white rats

Parameters

Control

Car

Levo

BPF

Car + Levo

Car + BPF

T4 μg/mL

      

 Mean ± SE

8.5 ± 1.7

3.95a** ± 0.8

20ab** ± 1.67

15.2ab** ± 2.29

7.6b** ± 1.17

8.0b** ± 1.12

 % of change (1)

 

− 53.5

 + 135.3

 + 78.8

− 10.5

− 5.88

 % of change (2)

  

 + 406

 + 284

 + 284.8

 + 102.5

T3 ng/mL

      

 Mean ± SE

1.75 ± 0.4

0.5a** ± 0.2

4.68ab** ± 0.5

5.3ab** ± 0.57

2.23a*b** ± 0.56

2.11b** ± 0.49

 % of change (1)

 

− 71.4

 + 162.8

 + 202.8

 + 27.4

 + 20.6

 % of change (2)

  

 + 820

 + 960

 + 346

 + 322

FT4 ng/dL

      

 Mean ± SE

1.34 ± 0.16

0.55a** ± 0.08

1.76a*b** ± 0.11

2.3ab** ± 0.24

1.2b** ± 0.14

1.6b** ± 0.19

 % of change (1)

 

− 58.9

 + 31.3

 + 71.6

− 10.4

 + 19.4

 % of change (2)

  

 + 220

 + 318

 + 118

 + 190.9

FT3 pg/mL

      

 Mean ± SE

2.93 ± 0.24

1.35a** ± 0.06

3.6a*b** ± 0.29

4.08a*b** ± 0.17

3.26b** ± 0.2

4.2a*b** ± 0.48

 % of change (1)

 

− 53.9

 + 22.86

 + 39.24

 + 11.26

 + 43.3

 % of change (2)

  

 + 166.6

 + 202.2

 + 141.48

 + 211

TSH μIu/mL

      

 Mean ± SE

3.3 ± 0.33

20.6a** ± 0.89

1.23ab** ± 0.25

0.98ab** ± 0.17

5.4a**b* ± 0.82

6.3ab** ± 0.61

 % of change (1)

 

 + 524

− 62.7

− 70.3

 + 62.4

 + 90.9

 % of change (2)

  

− 94

− 95

− 37.9

− 69

  1. Significant difference between control and different groups.N = 8.* P < 0.05 Significant. ** P < 0.001 Highly Significant. Non-Significant P > 0.05.% of change (1) different from normal control group G1.% of change (2) different from carbimazole group G2
  2. aSignificant different from control group
  3. bSignificant different from carbimazole group