Effect of a bradykinin potentiating factor separated from honey bee venom on thyroid gland and testis in hypothyroid white rats

The Journal of Basic and Applied Zoology

Table 2 Effect of BPF (2.314 mg/kg b.w) and Levothyroxine (100 μg/kg b.w) on serum LH, FSH and testosterone levelsof male albino rats induced by carbimazole (0.05 mg/kg b.w) for 60 days in different groups

Parameter	Control	Car	Levo	BPF	Car + Levo	Car + BPF
LH μIU/mL
Mean ± SE	6.35 ± 0.68	3.88^a* ± 0.64	8.46^ab* ± 1.14	10.47^ab** ± 0.66	6.45^b** ± 0.55	7.2^b** ± 0.72
% of change (1)		-38.8	+ 33.2	+ 64.8	+ 1.57	+ 13.5
% of change (2)			+ 118	+ 169.8	+ 66.2	+ 85.58
FSH μIU/mL
Mean ± SE	8.8 ± 0.92	5.0^a* ± 0.42	11.4^ab* ± 1.2	19.4^ab** ± 1.79	10.0^b** ± 0.76	9.65^b** ± 0.7
% of change (1)		-42	+ 29.7	+ 120	+ 13.6	+ 9.65
% of change (2)			+ 123.9	+ 280.4	+ 100	+ 93
Testosterone ng/dL
Mean ± SE	250 ± 3.6	190.2^a* ± 3.8	277.8^b* ± 2	353.5^ab* ± 3.0	239.3^b* ± 3.6	246.6^b* ± 3.0
% of change (1)		-24	+ 11	+ 41.4	-4.3	-1.4
% of change (2)			+ 46	+ 85.5	+ 25.8	+ 29.6

Significant difference between control and different groups. N = 8
*P < 0.05 Significant. **P < 0.001 Highly Significant. Non-Significant P > 0.05.% of change (1) different from normal control group G1.% of change (2) different from carbimazole group G2
^aSignificant different from control group
^bSignificant different from carbimazole group