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Table 2 Action of MECA on formalin-induced hind-paw oedema

From: Potential pharmacological properties of methanol leaves extract of Culcasia Angolensis (Araceae): antinociceptive, antiinflammatory and antipyretic activities in laboratory animals

Treatments (mg/kg)

Mean paw diameter (mm)

 

0 h

1 h

2 h

3 h

4 h

5 h

N/S (10 ml/kg)

2.30 ± 0.06

2.67 ± 0.10

3.12 ± 0.05

3.11 ± 0.05

3.01 ± 0.06

2.9 ± 0.06

MECA 125

2.22 ± 0.05

2.65 ± 0.06

2.71 ± 0.04

2.72 ± 0.04

2.53 ± 0.03**

2.41 ± 0.01*

MECA 250

2.35 ± 0.07

2.76 ± 0.02

2.77 ± 0.02

2.85 ± 0.06

2.55 ± 0.04**

2.40 ± 0.05**

MECA 500

2.20 ± 0.09

2.83 ± 0.03

2.82 ± 0.04

2.73 ± 0.03

2.51 ± 0.06**

2.31 ± 0.04**

KET (10)

2.23 ± 0.05

2.65 ± 0.06

2.74 ± 0.09

2.41 ± 0.04

2.31 ± 0.02**

2.14 ± 0.01**

  1. The values were analysed using repeated-measures ANOVA followed by Bonferroni post hoc test and presented as mean ± SEM
  2. MECA, methanol leaf extract of Culcasia angolensis; Ket, ketoprofen
  3. *p < 0.05, **p < 0.001 significant decrease in mean paw oedema compared to time zero; n = 6