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Table 3 Actions of the MECA on carrageenan-induced paw oedema

From: Potential pharmacological properties of methanol leaves extract of Culcasia Angolensis (Araceae): antinociceptive, antiinflammatory and antipyretic activities in laboratory animals

Treatments (mg/kg)

Mean paw diameter (mm)

1 h

2 h

3 h

4 h

5 h

N/S (10 ml/kg)

1.66 ± 0.144

2.72 ± 0.188

2.70 ± 0.407

3.38 ± 0.120

3.18 ± 0.121

MECA 125

1.56 ± 0.103

(6.02%)

2.30 ± 0.182

(15.4%)

2.44 ± 0.172

(9.6%)

2.42 ± 0.174

(28.4%)

2.54 ± 0.121

(27.3%)

MECA 250

1.22 ± 0.139

(26.5%)

2.16 ± 0.199

(20.6%)

1.88 ± 0.159

(30.4%)

1.64 ± 0.181

(51.5%) ***

1.68 ± 0.058

(54.5%) ***

MECA 500

1.42 ± 0.073

(14.5%)

2.36 ± 0.291

(13.2%)

1.38 ± 0.334

(48.9%)*

1.34 ± 0.172

(60.4%) ***

1.34 ± 0.157

(63.6%) ***

KET (10)

1.34 ± 0.160

(19.3%)

1.02 ± 0.073

(62.5%) ***

1.00 ± 0.327

(62.9%) **

1.00 ± 0.241 (70.4%) ***

1.52 ± 0.240

(63.6%) ***

  1. Values were analysed using repeated-measures ANOVA followed by Bonferroni post hoc test and presented as mean ± SEM
  2. MECA, methanol leaf extract of Culcasia angolensis; N/S, normal saline. Figures in parentheses (bold) represent percentage inhibition of inflammation (paw oedema)
  3. *p ≤ 0.05, **p ≤ 0.01, ***p < 0.001 related to the control group. n = 6