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Table 4 Actions of MECA on Brewer's yeast-induced pyrexia

From: Potential pharmacological properties of methanol leaves extract of Culcasia Angolensis (Araceae): antinociceptive, antiinflammatory and antipyretic activities in laboratory animals

Treatment (mg/kg)

Rectal temperature (°C) after 18 h

Initial

0 h

1 h

2 h

3 h

N/S(10 ml/kg)

37.33 ± 0.11

39.93 ± 0.11

39.98 ± 0.14

40.22 ± 0.49

39.87 ± 0.22

MECA(125)

37.21 ± 0.20

39.43 ± 0.19

39.40 ± 0.01

39.21 ± 0.15

38.65 ± 0.71*

MECA(250)

37.66 ± 0.43

39.61 ± 0.15

39.69 ± 0.41

39.01 ± 0.21

38.54 ± 0.41*

MECA(500)

37.44 ± 0.23

39.58 ± 0.11

38.42 ± 0.08

38.30 ± 0.11*

37.66 ± 0.43**

PCM (150)

37.32 ± 0.36

39.47 ± 0.17

37.44 ± 0.33**

36.68 ± 0.30**

37.19 ± 0.48**

  1. The values were analysed using repeated measure ANOVA followed by Bonferroni post hoc test and presented as mean ± SEM
  2. N/S, normal saline; PCM, paracetamol; MECA, Methanol leaf extract of Culcasia angolensis
  3. *p ≤ 0.05, **p ≤ 0.01 compared to control group; n = 6