Influence of hydroethanolic extract of Cassia spectabilis leaves on diclofenac-induced oxidative stress and hepatorenal damage in Wistar rats

The Journal of Basic and Applied Zoology

Table 1 Effect of hydroethanolic extract of Cassia spectabilis leaves on the serum enzyme activities in DF-treated rats

Treatment groups	Serum enzyme activities as markers of liver injuries in rats
Treatment groups	ALT (U/L)	AST (U/L)	ALP (U/L)	GGT (U/L)	LDH (U/L)
1. Normal control	11.7 ± 1.0	15.5 ± 0.8	117.8 ± 1.4	26.6 ± 0.9	13.5 ± 2.7
2. DF control	32.3 ± 1.1^a	47.3 ± 0.8^a	384.7 ± 1.7^a	95.5 ± 1.4^a	40.5 ± 4.2^a
3. DF + 100 mg CSE	24.4 ± 0.4^ab	32.9 ± 0.7^ab	267.8 ± 1.0^ab	75.2 ± 0.9^ab	37.7 ± 1.7^a
4. DF + 300 mg CSE	28.2 ± 0.4^ab	37.7 ± 0.6^ab	277.6 ± 0.6^ab	81.9 ± 0.6^ab	40.5 ± 2.9^a
5. DF + 500 mg CSE	15.2 ± 0.4^ab	20.7 ± 0.6^ab	234.9 ± 1.2^ab	57.5 ± 0.6^ab	29.7 ± 1.7^ab

Values are Mean ± SEM, n = 6
DF diclofenac sodium, CSE hydroethanolic extract of Cassia spectabilis leaf (mg/kg body weight), ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, GGT gamma glutamyl transferase, LDH lactate dehydrogenase
^aSignificantly different from the normal control (p < 0.05)
^bSignificantly different from the DF control (p < 0.05)