Influence of hydroethanolic extract of Cassia spectabilis leaves on diclofenac-induced oxidative stress and hepatorenal damage in Wistar rats

The Journal of Basic and Applied Zoology

Table 2 Effect of hydroethanolic extract of Cassia spectabilis leaves on the levels of serum proteins and bilirubin in DF-treated rats

Treatment groups	Serum proteins and bilirubin levels as markers of liver injuries in rats
Treatment groups	T-proteins (g/L)	Albumin (g/L)	Globulins (g/L)	T-bilirubin (µmol/L)	D-bilirubin (µmol/L)
1. Normal control	77.2 ± 1.09	38.7 ± 0.44	38.5 ± 0.85	9.8 ± 0.46	3.5 ± 0.19
2. DF control	56.6 ± 0.68^a	23.1 ± 0.62^a	33.6 ± 1.30^a	38.0 ± 0.74^a	24.2 ± 1.06^a
3. DF + 100 CSE	63.8 ± 0.32^ab	27.7 ± 0.26^ab	36.1 ± 0.28^ab	28.1 ± 0.74^ab	14.4 ± 0.50^ab
4. DF + 300 CSE	60.6 ± 0.32^ab	24.8 ± 0.17^ab	35.7 ± 0.38^a	32.9 ± 0.13^ab	17.8 ± 0.21^ab
5. DF + 500 CSE	72.1 ± 0.58^ab	34.7 ± 0.50^ab	37.4 ± 0.84^b	18.7 ± 0.45^ab	6.8 ± 0.57^ab

Values are Mean ± SEM, n = 6
DF diclofenac sodium, T total, D direct, CSE hydroethanolic extract of Cassia spectabilis leaf (mg/kg body weight)
^aSignificantly different from the normal control (p < 0.05)
^bSignificantly different from the diclofenac control (p < 0.05)