Influence of hydroethanolic extract of Cassia spectabilis leaves on diclofenac-induced oxidative stress and hepatorenal damage in Wistar rats

The Journal of Basic and Applied Zoology

Table 6 Effect of hydroethanolic extract of Cassia spectabilis leaves on the levels of serum MDA, GSH and G6Pase in DF-treated rats

Treatment groups	Levels of hepatorenal oxidative damage markers in rats
Treatment groups	G6Pase (ng/µL)	MDA (nmol/mg p)	GSH (µg/mL)
1. Normal control	33.89 ± 0.91	3.46 ± 0.20	64.44 ± 1.05
2. DF control	14.71 ± 0.44^a	14.44 ± 0.73^a	30.13 ± 0.86^a
3. DF + 100 mg/kg CSE	20.98 ± 0.71^ab	7.49 = 0.44^ab	37.13 ± 0.53^ab
4. DF + 300 mg/kg CSE	17.01 ± 0.59^ab	7.25 ± 0.24^ab	36.05 ± 0.80^ab
5. DF + 500 mg/kg CSE	27.26 ± 0.80^ab	4.74 ± 0.18^b	47.54 ± 0.74^ab

Values are Mean ± SEM, n = 6
DF diclofenac sodium, CSE Cassia spectabilis leaf extract, G6Pase glucose 6-phosphatase, MDA malon dialdehyde, GSH reduced glutathione
^aSignificantly different from the normal control (p < 0.05)
^bSignificantly different from the diclofenac control (p < 0.05)