Fig. 9

Effects of folic acid and Omeprazole on the cyto-architectural alteration induced by acetic acid in the rat’s stomach at day 5 and 10. a Normal stomach: No significant lesion, surface epithelial is intact. b Acetic acid treated (day 5): Severe ulceration involving the mucosa and submucosa with the production of cellular debris, there is replacement of the submucosa by connective tissue fibers. (Thin black arrow: fibrosis). c folic acid (2 mg/kg) treated (day 5): Mild congestion of the mucosa (thin blue arrow), severe oedema (orange arrow) of the submucosa. d Folic acid (3 mg/kg) treated (day 5): Moderate haemorrhage in the mucosa (blue arrow). e Omeprazole treated (day 5): Mild erosion of surface epithelial (black arrow) and mild inflammation of mucosa and submucosa. f Normal stomach (day 10): No significant lesion, surface epithelial is intact. g Acetic acid treated (day 10): Moderate ulcer, moderate infiltration of inflammatory cells within the mucosa, lamina propia and submucosa layer (Orange arrow: edema; Purple arrow: adipocytes). h Folic acid (2 mg/kg) treated (day 10): Mild oedema (orange arrow), mild inflammation of mucosa and submucosa. i Folic acid (3 mg/kg) treated (day 10): Moderate haemorrhage (blue arrow) of submucosa with mild inflammation of mucosa and submucosa. j Omeprazole treated (day 10): Slight oedema and slight inflammation of mucosa and submucosa (orange arrow). Surface epithelial is moderately preserved. (H & E, X100)