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Table 3 Effect of varying doses of folic acid on pyloric ligation induced gastric ulcer: gastric juice volume, pH and acid output

From: Folic acid protects and heals gastric mucosa: role of acid output, inflammatory cytokines, angiogenic and growth factors

Group Treatment Gastric juice volume (ml/6 h) pH Acid output (× 104 mmol/6 h)
1 Normal saline (1 ml/kg b.w) 3.80 ± 0.15 2.60 ± 0.01 5.20 ± 0.12
2 6 h Pyloric Ligation 6.50 ± 0.20a 1.45 ± 0.002a 8.20 ± 0.05a
3 2FA + 6 h Pyloric Ligation 4.00 ± 0.10b 2.00 ± 0.01 5.20 ± 0.03b
4 3FA + 6 h Pyloric Ligation 4.20 ± 0.12b 2.10 ± 0.02b 5.10 ± 0.01b
5 OMEP + 6 h Pyloric Ligation 3.50 ± 0.05c 2.90 ± 0.05c 4.00 ± 0.01c
  1. 2FA 2 mg/kg Folic acid, 3FA 3 mg/kg Folic acid, OMEP omeprazole
  2. aP < 0.05, Pyloric ligation versus control group
  3. bP < 0.05, 2FA + 6 h Pyloric Ligation versus 6 h Pyloric Ligation
  4. cP < 0.05, Omeprazole + 6 h Pyloric Ligation versus 6 h Pyloric Ligation only. (Mean ± SEM, n = 5)