Folic acid protects and heals gastric mucosa: role of acid output, inflammatory cytokines, angiogenic and growth factors

The Journal of Basic and Applied Zoology

Table 3 Effect of varying doses of folic acid on pyloric ligation induced gastric ulcer: gastric juice volume, pH and acid output

Group	Treatment	Gastric juice volume (ml/6 h)	pH	Acid output (× 10⁴ mmol/6 h)
1	Normal saline (1 ml/kg b.w)	3.80 ± 0.15	2.60 ± 0.01	5.20 ± 0.12
2	6 h Pyloric Ligation	6.50 ± 0.20^a	1.45 ± 0.002^a	8.20 ± 0.05^a
3	2FA + 6 h Pyloric Ligation	4.00 ± 0.10^b	2.00 ± 0.01	5.20 ± 0.03^b
4	3FA + 6 h Pyloric Ligation	4.20 ± 0.12^b	2.10 ± 0.02^b	5.10 ± 0.01^b
5	OMEP + 6 h Pyloric Ligation	3.50 ± 0.05^c	2.90 ± 0.05^c	4.00 ± 0.01^c

2FA 2 mg/kg Folic acid, 3FA 3 mg/kg Folic acid, OMEP omeprazole
^aP < 0.05, Pyloric ligation versus control group
^bP < 0.05, 2FA + 6 h Pyloric Ligation versus 6 h Pyloric Ligation
^cP < 0.05, Omeprazole + 6 h Pyloric Ligation versus 6 h Pyloric Ligation only. (Mean ± SEM, n = 5)