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Table 4 Effect of varying doses of folic acid on pyloric ligation induced gastric ulcer: pro-inflammatory and anti-inflammatory cytokines

From: Folic acid protects and heals gastric mucosa: role of acid output, inflammatory cytokines, angiogenic and growth factors

Group Treatment TNF-α (pg/mg protein) IL-1β (pg/mg protein) IL-4 (pg/mg protein) IL-10 (pg/mg protein)
1 Normal saline (1 ml/kg b.w) 15.5 ± 3.5 10.0 ± 3.5 50.5 ± 5.0 70.5 ± 5.0
2 6 h Pyloric Ligation 54.5 ± 5.0a 45.5 ± 5.0a 15.7 ± 2.0a 45.5 ± 5.0a
3 2FA + 6 h Pyloric Ligation 30.7 ± 2.5b 25.0 ± 2.5b 25.6 ± 1.5b 55.5 ± 2.0b
4 3FA + 6 h Pyloric Ligation 28.0 ± 5.0b 25.0 ± 5.0b 30.5 ± 4.5b 60.0 ± 2.5c
5 OMEP + 6 h Pyloric Ligation 25.0 ± 2.0c 20.0 ± 2.0c 40.5 ± 1.0c 65.9 ± 4.0d
  1. 2FA 2 mg/kg Folic acid, 3FA 3 mg/kg Folic acid, OMEP omeprazole
  2. aP < 0.05, Pyloric ligation versus control group
  3. bP < 0.05, 2FA + 6 h Pyloric Ligation versus 6 h Pyloric Ligation
  4. cP < 0.05, Omeprazole + 6 h Pyloric Ligation versus 6 h Pyloric Ligation only. (Mean ± SEM, n = 5)