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Table 5 Intensity of the immunoreactive EGFR, Ki-67, CD31 and Factor VIII positive cells in the ulcerated stomach treated with Folic acid (FA) and Omeprazole (OMEP)

From: Folic acid protects and heals gastric mucosa: role of acid output, inflammatory cytokines, angiogenic and growth factors

 

Day 5

Day 10

UC

FA (2 mg/kg)

FA (3 mg/kg)

OMEP

UC

FA (2 mg/kg)

FA (3 mg/kg)

OMEP

EGFR

+

+

+

++

+

++

+++

+++

Ki-67

+

+

+

++

++

++

+++

+++

CD31

+

+

+

+

++

++

+++

+++

Factor VIII

+

+

+

+

+

+

+++

+++

  1. UC acetic acid ulcer control, 2FA 2 mg/kg Folic acid, 3FA 3 mg/kg Folic acid, OMEP omeprazole
  2. −, No expression
  3. +, Very mild surface/deep expression
  4. ++, Mild and focal (< 50%) or diffuse (> 50%) surface or deep expression
  5. +++, Moderate focal or diffuse surface or deep expression