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Table 6 Tissue cytokines level in the acetic acid ulcerated stomach treated with Folic acid (FA) and Omeprazole (OMEP)

From: Folic acid protects and heals gastric mucosa: role of acid output, inflammatory cytokines, angiogenic and growth factors

  Day 5 Day 10
UC 2FA 3FA OMEP UC 2FA 3FA OMEP
TNF-α 75.5 ± 5.0 60.5 ± 3.0a 59.5 ± 5.0a 50.0 ± 2.0a 40.5 ± 2.0 30.2 ± 1.0a 30.5 ± 1.0a 20.6 ± 1.5a
IL-1β 80.4. ± 1.0 70.2 ± 1.5b 60.5 ± 1.2b 55.0 ± 1.0b 50.3 ± 1.2 28.5 ± 1.4b 27.5 ± 2.0b 15.5 ± 1.1b
IL-4 10.5. ± 1.0 25.7 ± 2.0c 30.8 ± 2.5c 35.0. ± 1.0c 20.0 ± 1.3 30.5 ± 0.5c 38.5 ± 1.5c 40.5 ± 0.8c
IL-10 30.0. ± 1.0d 50.9. ± 2.5d 50.0. ± 1.5d 57.5. ± 1.5d 50.5 ± 1.0 67.5 ± 0.5d 70.5 ± 0.4d 80.0 ± 1.2d
  1. UC acetic acid ulcer control, 2FA 2 mg/kg Folic acid, 3FA 3 mg/kg Folic acid, OMEP omeprazole
  2. *a,b,c,d p < 0.05 cf. ulcer control each group on day 5 and 10