Fig. 4

Photomicrographs from hematoxylin- and eosin-stained kidney sections of (A–D) MTX-treated rats showing separation of the capsule (double arrow) from the renal cortex by a wide space (star) containing hemorrhage (H), Malpighian corpuscles with damaged glomeruli (G), Bowman’s capsule (BC) and dilated Bowman’s spaces (arrowheads), proximal (PCT) and distal (DCT) convoluted tubules with dilated lumens (stars) and lining epithelial cells with vacuolated cytoplasm (V) and pyknotic nuclei (Py), congested renal artery (RA), leukocytic infiltration (LI) and fibers (F) and E&F) MTX and HPE-treated rats showing nearly normal Malpighian corpuscles with Bowman’s capsule (BC) with squamous epithelium (arrows), Bowman’s spaces (arrowheads) and glomeruli (G) and proximal (PCT) and distal (DCT) convoluted tubules (DCT)