From: The protective effect of naringenin against pyrazinamide-induced hepatotoxicity in male Wistar rats
Parameter | Time (days) | Experimental group | Treatment effect | |||
---|---|---|---|---|---|---|
Control | PZA | PZA + NGN | NGN | |||
WBC (X109L−1) | 7 | 9.23 ± 0.53a | 8.31 ± 0.19a | 8.63 ± 0.36a | 8.95 ± 0.42a | F3, 16 = 1.01, P = 0.414 |
14 | 9.33 ± 0.38b | 8.20 ± 0.30a | 9.32 ± 0.35b | 9.62 ± 0.27b | F3, 16 = 3.675, P = 0.035 | |
21 | 9.18 ± 0.28b | 7.88 ± 0.25a | 9.51 ± 0.15b | 9.55 ± 0.12b | F3, 16 = 13.79, P = 0.000 | |
28 | 9.21 ± 0.49b | 7.09 ± 0.15a* | 9.07 ± 0.34b | 9.03 ± 0.25b | F3, 16 = 9.167, P = 0.001 | |
r | – | − 0.67 | + 0.24 | + 0.03 | ||
Time effect | F3, 16 = 0.023, P = 0.995 | F3, 16 = 5.757, P = 0.007 | F3, 16 = 1.446, P = 0.267 | F3, 16 = 1.462, P = 0.262 | ||
RBC (X1012L−1) | 7 | 7.42 ± 0.26a | 7.06 ± 0.07a | 7.04 ± 0.05a | 7.37 ± 0.33a | F3, 16 = 0.837, P = 0.493 |
14 | 7.42 ± 0.14a | 7.05 ± 0.16a | 7.48 ± 0.17a | 7.42 ± 0.10a | F3, 16 = 2.12, P = 0.138 | |
21 | 7.46 ± 0.20b | 6.57 ± 0.13a | 7.41 ± 0.21b | 7.62 ± 0.15b | F3, 16 = 7.407, P = 0.002 | |
28 | 7.67 ± 0.25b | 6.56 ± 0.24a | 7.49 ± 0.14b | 7.62 ± 0.20b | F3, 16 = 8.434, P = 0.001 | |
r | – | − 0.54 | + 0.40 | + 0.20 | ||
Time effect | F3, 16 = 0.308, P = 0.819 | F3, 16 = 2.968, P = 0.063 | F3, 16 = 1.98, P = 0.158 | F3, 16 = 2.89, P = 0.068 | ||
Hb content (g dL−1) | 7 | 13.42 ± 0.36a | 13.38 ± 0.20a | 13.82 ± 0.24a | 13.57 ± 0.20a | F3, 16 = 0.597, P = 0.626 |
14 | 13.62 ± 0.15a | 13.34 ± 0.20a | 13.53 ± 0.19a | 13.83 ± 0.13a | F3, 16 = 1.395, P = 0.280 | |
21 | 13.72 ± 0.27b | 12.86 ± 0.13a | 13.72 ± 0.16b | 13.76 ± 0.14b | F3, 16 = 5.484, P = 0.009 | |
28 | 13.64 ± 0.32b | 12.80 ± 0.18a | 13.84 ± 0.36b | 13.91 ± 0.13b | F3, 16 = 3.697, P = 0.034 | |
r | – | − 0.55 | + 0.05 | + 0.33 | ||
Time effect | F3, 16 = 0.199, P = 0.895 | F3, 16 = 2.889, P = 0.068 | F3, 16 = 0.318, P = 0.812 | F3, 16 = 0.905, P = 0.46 | ||
PCV (%) | 7 | 40.24 ± 1.03a | 40.32 ± 0.74a | 40.44 ± 0.87a | 40.80 ± 0.45a | F3, 16 = 0.095, P = 0.962 |
14 | 41.10 ± 0.84a | 40.60 ± 0.42a | 41.18 ± 0.47a | 41.30 ± 0.58a | F3, 16 = 0.263, P = 0.851 | |
21 | 41.68 ± 0.59b | 38.44 ± 0.91a | 41.67 ± 0.21b | 41.28 ± 0.39b | F3, 16 = 7.149, P = 0.003 | |
28 | 41.64 ± 0.51b | 38.46 ± 0.54a | 41.58 ± 0.31b | 41.44 ± 0.41b | F3, 16 = 11.73, P = 0.000 | |
r | – | − 0.51 | + 0.38 | + 0.22 | ||
Time effect | F3, 16 = 0.754, P = 0.536 | F3, 16 = 2.954, P = 0.064 | F3, 16 = 1.123, P = 0.369 | F3, 16 = 0.367, P = 0.778 |