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Table 1 The white and red blood cells (WBC & RBC) counts, hemoglobin (Hb) content and packed cell volume (PCV) of the control rats and those orally administrated PZA alone, NGN 1 h prior to PZA, and NGN alone, every day for 7, 14, 21 & 28 days. Data are displayed as mean (of 5 rats) ± standard error of mean

From: The protective effect of naringenin against pyrazinamide-induced hepatotoxicity in male Wistar rats

Parameter

Time

(days)

Experimental group

Treatment effect

Control

PZA

PZA + NGN

NGN

WBC

(X109L−1)

7

9.23 ± 0.53a

8.31 ± 0.19a

8.63 ± 0.36a

8.95 ± 0.42a

F3, 16 = 1.01, P = 0.414

14

9.33 ± 0.38b

8.20 ± 0.30a

9.32 ± 0.35b

9.62 ± 0.27b

F3, 16 = 3.675, P = 0.035

21

9.18 ± 0.28b

7.88 ± 0.25a

9.51 ± 0.15b

9.55 ± 0.12b

F3, 16 = 13.79, P = 0.000

28

9.21 ± 0.49b

7.09 ± 0.15a*

9.07 ± 0.34b

9.03 ± 0.25b

F3, 16 = 9.167, P = 0.001

r

 − 0.67

 + 0.24

 + 0.03

 
 

Time effect

F3, 16 = 0.023, P = 0.995

F3, 16 = 5.757, P = 0.007

F3, 16 = 1.446, P = 0.267

F3, 16 = 1.462, P = 0.262

 

RBC

(X1012L−1)

7

7.42 ± 0.26a

7.06 ± 0.07a

7.04 ± 0.05a

7.37 ± 0.33a

F3, 16 = 0.837, P = 0.493

14

7.42 ± 0.14a

7.05 ± 0.16a

7.48 ± 0.17a

7.42 ± 0.10a

F3, 16 = 2.12, P = 0.138

21

7.46 ± 0.20b

6.57 ± 0.13a

7.41 ± 0.21b

7.62 ± 0.15b

F3, 16 = 7.407, P = 0.002

28

7.67 ± 0.25b

6.56 ± 0.24a

7.49 ± 0.14b

7.62 ± 0.20b

F3, 16 = 8.434, P = 0.001

r

 − 0.54

 + 0.40

 + 0.20

 
 

Time effect

F3, 16 = 0.308, P = 0.819

F3, 16 = 2.968, P = 0.063

F3, 16 = 1.98, P = 0.158

F3, 16 = 2.89, P = 0.068

 

Hb content

(g dL−1)

7

13.42 ± 0.36a

13.38 ± 0.20a

13.82 ± 0.24a

13.57 ± 0.20a

F3, 16 = 0.597, P = 0.626

14

13.62 ± 0.15a

13.34 ± 0.20a

13.53 ± 0.19a

13.83 ± 0.13a

F3, 16 = 1.395, P = 0.280

21

13.72 ± 0.27b

12.86 ± 0.13a

13.72 ± 0.16b

13.76 ± 0.14b

F3, 16 = 5.484, P = 0.009

28

13.64 ± 0.32b

12.80 ± 0.18a

13.84 ± 0.36b

13.91 ± 0.13b

F3, 16 = 3.697, P = 0.034

r

 − 0.55

 + 0.05

 + 0.33

 
 

Time effect

F3, 16 = 0.199, P = 0.895

F3, 16 = 2.889, P = 0.068

F3, 16 = 0.318, P = 0.812

F3, 16 = 0.905, P = 0.46

 

PCV (%)

7

40.24 ± 1.03a

40.32 ± 0.74a

40.44 ± 0.87a

40.80 ± 0.45a

F3, 16 = 0.095, P = 0.962

14

41.10 ± 0.84a

40.60 ± 0.42a

41.18 ± 0.47a

41.30 ± 0.58a

F3, 16 = 0.263, P = 0.851

21

41.68 ± 0.59b

38.44 ± 0.91a

41.67 ± 0.21b

41.28 ± 0.39b

F3, 16 = 7.149, P = 0.003

28

41.64 ± 0.51b

38.46 ± 0.54a

41.58 ± 0.31b

41.44 ± 0.41b

F3, 16 = 11.73, P = 0.000

r

 − 0.51

 + 0.38

 + 0.22

 
 

Time effect

F3, 16 = 0.754, P = 0.536

F3, 16 = 2.954, P = 0.064

F3, 16 = 1.123, P = 0.369

F3, 16 = 0.367, P = 0.778

 
  1. P < 0.05, P < 0.01, P < 0.000: represents significant effects. *: represent significant (P < 0.05) differences as compared to 7th day
  2. r: Pearson’s correlation coefficient of the studied parameters with the experimental time
  3. In the same row, according to Duncan’s test, means marked with the same small superscript letters are insignificantly different (P > 0.05), whereas those marked with different ones are significantly different (P < 0.05)