Table 3 The levels of total protein (TP), albumin, globulin and albumin/globulin ratio in serum of the control rats and those orally administrated PZA alone, NGN 1 h prior to PZA, and NGN alone, every day for 7, 14, 21 & 28 days. Data are displayed as mean (of 5 rats) ± standard error of mean

TP

(g dL⁻¹)

7

6.58 ± 0.21^a

6.83 ± 0.17^a

6.74 ± 0.13^a

6.57 ± 0.19^a

F_{3, 16} = 0.509, P = 0.681

14

6.53 ± 0.21^a

6.72 ± 0.12^a

6.88 ± 0.18^a

6.86 ± 0.20^a

F_{3, 16} = 0.792, P = 0.516

21

6.61 ± 0.16^a

6.95 ± 0.05^a

6.88 ± 0.14^a

6.86 ± 0.17^a

F_{3, 16} = 1.126, P = 0.368

28

6.80 ± 0.09^a

6.67 ± 0.10^a

6.69 ± 0.08^a

6.86 ± 0.08^a

F_{3, 16} = 0.997, P = 0.419

r

–

 − 0.11

 − 0.06

 + 0.27

Time effect

F_{3, 16} = 0.447, P = 0.723

F_{3, 16} = 1.056, P = 0.395

F_{3, 16} = 0.49, P = 0.694

F_{3, 16} = 0.75, P = 0.538

Albumin

(g dL⁻¹)

7

3.72 ± 0.17^a

3.69 ± 0.04^a

3.56 ± 0.08^a

3.58 ± 0.07^a

F_{3, 16} = 0.595, P = 0.627

14

3.77 ± 0.14^a

3.67 ± 0.11^a

3.68 ± 0.10^a

3.63 ± 0.14^a

F_{3, 16} = 0.246, P = 0.863

21

3.72 ± 0.15^b

2.99 ± 0.23^a*

3.67 ± 0.07^b

3.74 ± 0.06^b

F_{3, 16} = 6.326, P = 0.005

28

3.70 ± 0.15^b

2.89 ± 0.16^a*

3.80 ± 0.05^b

3.84 ± 0.09^b

F_{3, 16} = 14.51, P = 0.000

r

–

 − 0.72

 + 0.46

 + 0.46

Time effect

F_{3, 16} = 0.044, P = 0.987

F_{3, 16} = 8.33, P = 0.001

F_{3, 16} = 1.704, P = 0.206

F_{3, 16} = 1.469, P = 0.26

Globulin

(g dL⁻¹)

7

2.87 ± 0.09^a

3.14 ± 0.13^a

3.18 ± 0.06^a

2.99 ± 0.12^a

F_{3, 16} = 1.838, P = 0.181

14

2.96 ± 014^a

3.05 ± 0.04^a

3.20 ± 0.09^a

3.23 ± 0.09^a

F_{3, 16} = 1.749, P = 0.197

21

3.09 ± 0.09^a

3.76 ± 0.15^b*

3.21 ± 0.07^a

3.12 ± 0.12^a

F_{3, 16} = 7.94, P = 0.002

28

3.10 ± 0.07^a

3.79 ± 0.07^b*

3.00 ± 0.10^a

3.02 ± 0.01^a

F_{3, 16} = 27.54, P = 0.000

r

–

 + 0.74

 − 0.31

 − 0.01

Time effect

F_{3, 16} = 1.199, P = 0.342

F_{3, 16} = 13.09, P = 0.000

F_{3, 16} = 1.303, P = 0.308

F_{3, 16} = 1.348, P = 0.294

Albumin /

globulin

(%)

7

1.21 ± 0.04^a

1.19 ± 0.04^a

1.12 ± 0.02^a

1.20 ± 0.03^a

F_{3, 16} = 1.69, P = 0.209

14

1.22 ± 0.03^a

1.20 ± 0.04^a

1.15 ± 0.02^a

1.16 ± 0.03^a

F_{3, 16} = 1.01, P = 0.415

21

1.16 ± 0.01^b

0.86 ± 0.08^a*

1.15 ± 0.01^b

1.20 ± 0.03^b

F_{3, 16} = 12.96, P = 0.000

28

1.20 ± 0.05^b

0.77 ± 0.05^a*

1.18 ± 0.05^b

1.20 ± 0.04^b

F_{3, 16} = 19.27, P = 0.000

r

–

 − 0.80

 + 0.36

 + 0.03

Time effect

F_{3, 16} = 0.411, P = 0.748

F_{3, 16} = 15.91, P = 0.000

F_{3, 16} = 0.952, P = 0.439

F_{3, 16} = 0.351, P = 0.789