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Fig. 2 | The Journal of Basic and Applied Zoology

Fig. 2

From: Protective effect of curcumin on the kidney of diclofenac sodium-challenged mice: apoptotic, redox potential and histopathological outcomes

Fig. 2

Photomicrographs of paraffin sections stained with Hematoxylin and Eosin (HX&E) illustrated the protective effect of curcumin on diclofenac sodium induced renal damage in rat. A The kidney of control (Ctrl) group showed normal architecture of renal corpuscles (RC) and proximal tubules (PT). B The kidney of diclofenac sodium (DS) group showed degenerated renal corpuscles (DRC) and degenerated proximal tubules (DPC). C The kidney of diclofenac sodium + curcumin (DS + Cur) group showed restoration of the normal architecture of renal corpuscles (RC) and proximal tubules (PC). D The kidney of Ctrl group showed normal-sized glomerulus (G) and Bowman’s space (BS), along with continuous healthy parietal layer of Bowman’s capsule (arrow) and normal proximal tubules (PT). E The kidney of DS group showed small-sized glomerulus (G), wide Bowman’s space (BS), destructed parietal layer of Bowman’s capsule (arrow) and degenerated proximal tubules (DPC). F The kidney of DS + Cur group showed the restoration of the normal size of the glomerulus (G) and Bowman’s space (BS), along with continuous healthy parietal layer of Bowman’s capsule (arrow) and normal proximal tubules (PT). G The kidney of Ctrl group showed normal-sized glomerulus (G) and Bowman’s space (BS) and normal macula densa cells of juxtaglomerular apparatus (MD). H The kidney of DS group showed small-sized glomerulus (G), wide Bowman’s space (BS) and detached macula densa cells of juxtaglomerular apparatus (DMD). I The kidney of DS + Cur group showed restoration of the normal size of the glomerulus (G) and Bowman’s space (BS) and normal macula densa cells of juxtaglomerular apparatus (MD). Original magnification (A–C) X200, scale bar = 100 μm, (D–I) X400, scale bar = 50 μm

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