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Table 1 Effects of curcumin on kidney function parameters and oxidant/antioxidant balance of diclofenac sodium-challenged mice

From: Protective effect of curcumin on the kidney of diclofenac sodium-challenged mice: apoptotic, redox potential and histopathological outcomes

Parameter

Group

Control

DS

DS + Cur

p value

Plasma urea level (mg/dl)

53.761 ± 3.556

65.000 ± 6.380

33.561 ± 3.049bc

0.001

Plasma creatinine level (mg/dl)

0.407 ± 0.024

0.422 ± 0.014

0.486 ± 0.031

0.098

Plasma TAC level (mM/l)

0.043 ± 0.005

0.068 ± 0.005a

0.062 ± 0.007c

0.022

Renal LPO level (nmol/mg protein)

2.193 ± 0.306

1.864 ± 0.167

1.673 ± 0.187

0.302

Renal CAT activity (U/mg protein)

3.843 ± 0.193

2.655 ± 0.383a

0.935 ± 0.162bc

0.000

Renal GSH level (μg/mg protein)

34.494 ± 1.604

61.039 ± 6.927a

33.165 ± 3.670b

0.002

  1. Results are expressed as mean ± SEM (6 mice/group)
  2. Data are analyzed by one-way ANOVA followed by Duncan posttest
  3. DS Diclofenac sodium; Cur curcumin; TAC total antioxidant capacity; LPO lipid peroxides; CAT catalase; GSH reduced glutathione
  4. aindicates significant difference between control and DS groups at p < 0.05
  5. bindicates significant difference between DS and DS + Cur groups at p < 0.05
  6. cindicates significant difference between control and DS + Cur groups at p < 0.05