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Fig. 14 | The Journal of Basic and Applied Zoology

Fig. 14

From: A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

Fig. 14

Effect of EGCG on Fl induced ultra changes in the hippocampus by transmission of electron microphotographs in the hippocampus of control and experimental animals (ad). a Control rats: normal neurons are shown condensed, regularly shaped, round nucleous (N) and nucleoulus (NL) in normal cells. b EGCG-treated rats: the ultrastructure of cytoplasm (CP) and cytoplasmic organelles showed a normal appearance of nucleous (N), mitochondria (M), and nucleoulus (NL). c Fl-treated rats: disintegrating neuron containing shrunken cytoplasm (SC), slightly dilated cisternae (DC) of endoplasmic reticulum and swollen mitochondria (SM) were observed. Typical necrotic neurons had smaller clumps of irregularly shaped, condensed chromatin with nuclear membrane breakdown. d Fl-treated rats with EGCG: EGCG treatment was effectively preventing the abovementioned findings, compared to control (NL: nucleolus, N: nucleus, CP: cytoplasm, DC: dilated cisternae SC: shrunken cytoplasm, SM: swollen mitochondria (scale bars, 1 μm)

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